Quorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, India.
Department of Industrial and Engineering Chemistry, Institute of Chemical Technology, Bhubaneswar, India.
Front Cell Infect Microbiol. 2023 May 23;13:1139026. doi: 10.3389/fcimb.2023.1139026. eCollection 2023.
Advancements in biomedical devices are ingenious and indispensable in health care to save millions of lives. However, microbial contamination paves the way for biofilm colonisation on medical devices leading to device-associated infections with high morbidity and mortality. The biofilms elude antibiotics facilitating antimicrobial resistance (AMR) and the persistence of infections. This review explores nature-inspired concepts and multi-functional approaches for tuning in next-generation devices with antibacterial surfaces to mitigate resistant bacterial infections. Direct implementation of natural inspirations, like nanostructures on insect wings, shark skin, and lotus leaves, has proved promising in developing antibacterial, antiadhesive, and self-cleaning surfaces, including impressive SLIPS with broad-spectrum antibacterial properties. Effective antimicrobial touch surfaces, photocatalytic coatings on medical devices, and conventional self-polishing coatings are also reviewed to develop multi-functional antibacterial surfaces to mitigate healthcare-associated infections (HAIs).
生物医学设备的进步在医疗保健领域独具匠心且不可或缺，拯救了数以百万计的生命。然而，微生物污染为生物膜在医疗器械上的定植铺平了道路，导致了与设备相关的感染，发病率和死亡率都很高。生物膜逃避抗生素，从而助长了抗生素耐药性（AMR）和感染的持续存在。本综述探讨了受自然启发的概念和多功能方法，用于调整具有抗菌表面的下一代设备，以减轻耐药细菌感染。直接实施自然灵感，例如昆虫翅膀、鲨鱼皮和荷叶上的纳米结构，已被证明在开发具有抗菌、抗粘连和自清洁表面方面很有前景，包括具有广谱抗菌性能的令人印象深刻的 SLIPS。还回顾了有效的抗菌触摸表面、医疗器械上的光催化涂层和传统的自抛光涂层，以开发多功能抗菌表面来减轻与医疗保健相关的感染（HAIs）。
