Antifungal potential of extracts, fractions and compounds from (Annonaceae) and (Rubiaceae).

Phytochemical study of afforded an alkaloid, 8,9-dimethoxy-5-phenanthridin-6-one (), isolated and characterised (assignment of H and C NMR) for the first time from a natural source along with two flavonoids, (2S)-5-hydroxy-7,8-dimethoxyflavanone () and (2S)-7-hydroxy-5-methoxy-6,8-dimethylflavone (). Clethric acid (), oleanoic acid (), β-sitosterol 3-O-β-D-glucopyranoside (), β-sitosterol palmitate () and a mixture of stigmasterol () and β-sitosterol () were isolated from . The structures of these compounds were elucidated using modern spectroscopic techniques including1D and 2D Nuclear Magnetic Resonance (NMR) Spectroscopy (H, C, H-H COSY, HSQC, HMBC) and Mass Spectrometry. Some fractions and compounds from exhibited good antifungal activity against clinical isolates and standard strains of yeast species of and genera while extracts from displayed weak antifungal activity. The results obtained show that could be a potential source of antifungal drugs.