Voutsadakis Ioannis A
Division of Medical Oncology, Department of Internal Medicine, Sault Area Hospital, Sault Ste Marie, ON, Canada; Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada.
Eur J Obstet Gynecol Reprod Biol. 2021 Jan;256:172-178. doi: 10.1016/j.ejogrb.2020.11.021. Epub 2020 Nov 12.
Serous ovarian carcinoma is the most common histological type of ovarian cancer, with high-grade serous ovarian carcinoma (HGSOC) being more common than low-grade serous ovarian carcinoma (LGSOC). Despite pathogenic and clinical differences, both grades of serous ovarian carcinoma share the propensity to express receptors for the female hormones - oestrogen (ERs) and progesterone receptors (PRs) - albeit in differing frequencies.
Systematic review and meta-analysis of studies reporting the expression of hormone receptors in LGSOC, and comparison with expression in HGSOC.
Expression of ERs is observed in 80.7 % of patients with LGSOC [95 % confidence interval (CI) 72.2-89.1 %] and 61.5 % of patients with HGSOC (95 % CI 38.8-84.1 %). Expression of PRs is observed in 54.4 % of patients with LGSOC (95 % CI 44.3-64.4 %) and 30.7 % of patients with HGSOC (95 % CI 15.7-45.7 %).
A higher percentage of LGSOCs are positive for ER expression compared with HGSOCs. Similarly, a higher percentage of LGSOCs are positive for PR expression, although PR expression is lower than ER expression. Expression of hormone receptors may represent a therapeutic opportunity for treatment with agents that block their activity, especially in LGSOC which is less responsive to chemotherapy and therapeutic options are limited.
浆液性卵巢癌是卵巢癌最常见的组织学类型，高级别浆液性卵巢癌（HGSOC）比低级别浆液性卵巢癌（LGSOC）更常见。尽管在致病机制和临床方面存在差异，但这两种级别的浆液性卵巢癌都有表达女性激素受体——雌激素受体（ERs）和孕激素受体（PRs）的倾向，尽管表达频率不同。
对报告LGSOC中激素受体表达的研究进行系统评价和荟萃分析，并与HGSOC中的表达情况进行比较。
80.7%的LGSOC患者（95%置信区间[CI]72.2 - 89.1%）观察到ERs表达，61.5%的HGSOC患者（95%CI 38.8 - 84.1%）观察到ERs表达。54.4%的LGSOC患者（95%CI 44.3 - 64.4%）观察到PRs表达，30.7%的HGSOC患者（95%CI 15.7 - 45.7%）观察到PRs表达。
与HGSOC相比，LGSOC中ER表达阳性的比例更高。同样，LGSOC中PR表达阳性的比例更高，尽管PR表达低于ER表达。激素受体的表达可能为使用阻断其活性的药物进行治疗提供机会，特别是在对化疗反应较差且治疗选择有限的LGSOC中。
