Vanderschueren-Lodeweyckx M, Van den Broeck J, Wolter R, Malvaux P
Department of Paediatric and Adolescent Endocrinology, University of Leuven, Belgium.
Acta Paediatr Scand Suppl. 1987;337:4-11. doi: 10.1111/j.1651-2227.1987.tb17121.x.
Retrospective growth data for 34 hGH deficient patients who had been treated for at least 3 years with hGH were analysed in a Belgian multicentre study. Final height was related to target height and was usually below it, but it was not determined by chronological or bone ages, bone age delay, height velocity before or during therapy, nor by duration of treatment. Total height gain during long-term substitution with hGH is inversely related to chronological and bone ages at the start of therapy, and is positively related to the duration of therapy. Early diagnosis of hGH deficiency is thus important, as it allows catch-up growth to optimal height before puberty, which in turn results in a good pubertal growth spurt.
在比利时的一项多中心研究中，分析了34例接受hGH治疗至少3年的生长激素缺乏患者的回顾性生长数据。最终身高与靶身高相关，通常低于靶身高，但它不是由实际年龄或骨龄、骨龄延迟、治疗前或治疗期间的身高增长速度，也不是由治疗持续时间决定的。长期使用hGH替代治疗期间的总身高增长与治疗开始时的实际年龄和骨龄呈负相关，与治疗持续时间呈正相关。因此，生长激素缺乏的早期诊断很重要，因为它能使青春期前的身高追赶至最佳高度，进而带来良好的青春期生长突增。
