Albertsson-Wikland K
Department of Paediatrics II, University of Gothenburg, Sweden.
Acta Paediatr Scand Suppl. 1987;337:110-6. doi: 10.1111/j.1651-2227.1987.tb17138.x.
hGH has been used in the treatment of hGH deficient children for nearly 30 years. The optimum treatment regimen is, however, still unknown. Generally, administration has been by 2 or 3 intramuscular injections/week and the total weekly dose has been 0.3-0.5 IU/kg. Many factors are known to influence the effect of treatment, such as the dose and the age of the child. In animal studies, the optimum growth rate occurs when the physiological pulse frequency of growth hormone is simulated (i.e. intravenous infusions of growth hormone every 3 hours in the rat). In humans, optimal growth rates occur in children in whom the spontaneous secretion of hGH is associated with many peaks (pulses) of high amplitude. In hGH deficient children, growth rate increases when the weekly dose of hGH is administered daily rather than 2-3 times/week, thereby optimizing the body's utilization of the hormone. The hGH plasma profile after daily subcutaneous hGH injections is, however, different from the hGH plasma profiles of children growing normally, in whom hGH secretion is episodic with many sharp pulses during the day and night. Whether simulation of normal hGH plasma profiles will increase the growth rate in hGH deficient children and normalize their adult height requires further investigation.
人生长激素（hGH）已用于治疗生长激素缺乏儿童近30年。然而，最佳治疗方案仍不明确。一般来说，给药方式是每周进行2或3次肌肉注射，每周总剂量为0.3 - 0.5国际单位/千克。已知许多因素会影响治疗效果，如剂量和儿童年龄。在动物研究中，当模拟生长激素的生理脉冲频率时（即大鼠每3小时静脉输注生长激素），会出现最佳生长速率。在人类中，最佳生长速率出现在人生长激素自发分泌与许多高幅度峰值（脉冲）相关的儿童身上。在生长激素缺乏儿童中，当每周的生长激素剂量每日给药而非每周2 - 3次给药时，生长速率会增加，从而优化身体对该激素的利用。然而，每日皮下注射生长激素后的血浆生长激素水平分布与正常生长儿童的血浆生长激素水平分布不同，正常生长儿童的生长激素分泌是间歇性的，白天和夜间有许多尖锐的脉冲。模拟正常血浆生长激素水平分布是否会提高生长激素缺乏儿童的生长速率并使其成年身高正常化，还需要进一步研究。
