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胰岛素样生长因子 2 mRNA 结合蛋白家族在人胰腺癌中的表达与预后分析。

Expression and prognostic analyses of the insulin-like growth factor 2 mRNA binding protein family in human pancreatic cancer.

机构信息

Department of General Surgery, the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, 68 Pohu Middle Road, Changzhou, Jiangsu, 213000, P.R. China.

Nanjing Medical University, Nanjing, Jiangsu, 211166, P.R. China.

出版信息

BMC Cancer. 2020 Nov 27;20(1):1160. doi: 10.1186/s12885-020-07590-x.

DOI:10.1186/s12885-020-07590-x
PMID:33246429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7694419/
Abstract

BACKGROUND

Despite advances in early diagnosis and treatment, cancer remains the leading cause of mortality worldwide. The insulin-like growth factor 2 mRNA binding protein (IGF2BP) family has been reported to be involved in a variety of human malignant tumours. However, little is known about their expression and prognostic value in human pancreatic cancer. Therefore, we performed a detailed cancer versus normal differential analysis.

METHODS

The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis (GEPIA) databases were used to analyse the mRNA expression levels of the IGF2BP family in various cancers, including pancreatic cancer. Then, the LinkedOmics and GEPIA databases were used to assess the relation between the expression levels of IGF2BPs and overall survival (OS). Then, univariate and multivariate Cox regression analyses were performed, and subgroups based on grade and stage were analysed. The signalling pathways associated with IGF2BP2 and IGF2BP3 were then investigated via gene set enrichment analysis (GSEA).

RESULTS

IGF2BP2 and IGF2BP3 were associated with each subset of OS based on grade and stage. Further clinical correlation analysis of IGF2BP2 and IGF2BP3 confirmed that IGF2BP2 and IGF2BP3 are fundamental factors in promoting pancreatic cancer progression.

CONCLUSION

IGF2BP2 and IGF2BP3 are key factors in promoting the progression of pancreatic cancer and are closely related to overall survival.

摘要

背景

尽管早期诊断和治疗取得了进展，但癌症仍然是全球主要的死亡原因。胰岛素样生长因子 2 mRNA 结合蛋白（IGF2BP）家族已被报道参与多种人类恶性肿瘤。然而，关于它们在人类胰腺癌中的表达和预后价值知之甚少。因此，我们进行了详细的癌症与正常的差异分析。

方法

使用癌症基因组图谱（TCGA）和基因表达谱交互分析（GEPIA）数据库分析 IGF2BP 家族在包括胰腺癌在内的各种癌症中的 mRNA 表达水平。然后，使用 LinkedOmics 和 GEPIA 数据库评估 IGF2BPs 的表达水平与总生存期（OS）之间的关系。然后进行单变量和多变量 Cox 回归分析，并根据分级和分期分析亚组。然后通过基因集富集分析（GSEA）研究与 IGF2BP2 和 IGF2BP3 相关的信号通路。

结果

IGF2BP2 和 IGF2BP3 与基于分级和分期的每个 OS 亚组相关。IGF2BP2 和 IGF2BP3 的进一步临床相关性分析证实，IGF2BP2 和 IGF2BP3 是促进胰腺癌进展的基本因素。

结论

IGF2BP2 和 IGF2BP3 是促进胰腺癌进展的关键因素，与总生存期密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/9ca56bbbdc23/12885_2020_7590_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/20dd88f023d1/12885_2020_7590_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/a9d254cce2e3/12885_2020_7590_Fig2_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/84760209f442/12885_2020_7590_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/46a79a9389ed/12885_2020_7590_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/0b76d1a8015a/12885_2020_7590_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/24c8686adbf9/12885_2020_7590_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/05045d3fa5d4/12885_2020_7590_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/9ca56bbbdc23/12885_2020_7590_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/20dd88f023d1/12885_2020_7590_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/a9d254cce2e3/12885_2020_7590_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/f1af1c3b5b57/12885_2020_7590_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/84760209f442/12885_2020_7590_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/46a79a9389ed/12885_2020_7590_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/0b76d1a8015a/12885_2020_7590_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/24c8686adbf9/12885_2020_7590_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/05045d3fa5d4/12885_2020_7590_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aef/7694419/9ca56bbbdc23/12885_2020_7590_Fig9_HTML.jpg

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