Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Wenzhou Medical University, No 109 Xueyuan West Road, Wenzhou, Zhejiang, 325027, China.
Mol Cancer. 2020 Nov 28;19(1):167. doi: 10.1186/s12943-020-01287-2.
Evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in the carcinogenesis and progression of a wide variety of human malignancies including colon cancer. In this review, we describe the functions and mechanisms of lncRNAs involved in colon oncogenesis, such as HOTAIR, PVT1, H19, MALAT1, SNHG1, SNHG7, SNHG15, TUG1, XIST, ROR and ZEB1-AS1. We summarize the roles of lncRNAs in regulating cell proliferation, cell apoptotic death, the cell cycle, cell migrative and invasive ability, epithelial-mesenchymal transition (EMT), cancer stem cells and drug resistance in colon cancer. In addition, we briefly highlight the functions of circRNAs in colon tumorigenesis and progression, including circPPP1R12A, circPIP5K1A, circCTIC1, circ_0001313, circRNA_104916 and circRNA-ACAP2. This review provides the rationale for anticancer therapy via modulation of lncRNAs and circular RNAs (circRNAs) in colon carcinoma.
证据表明，长非编码 RNA（lncRNA）在包括结肠癌在内的多种人类恶性肿瘤的发生和发展中起着至关重要的作用。在这篇综述中，我们描述了参与结肠癌发生的 lncRNA 的功能和机制，如 HOTAIR、PVT1、H19、MALAT1、SNHG1、SNHG7、SNHG15、TUG1、XIST、ROR 和 ZEB1-AS1。我们总结了 lncRNA 在调节细胞增殖、细胞凋亡、细胞周期、细胞迁移和侵袭能力、上皮-间充质转化（EMT）、癌症干细胞和结肠癌耐药性中的作用。此外，我们简要地强调了 circRNA 在结肠癌发生和发展中的作用，包括 circPPP1R12A、circPIP5K1A、circCTIC1、circ_0001313、circRNA_104916 和 circRNA-ACAP2。本综述为通过调节结肠癌中的 lncRNA 和环状 RNA（circRNA）进行抗癌治疗提供了依据。
