College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Nucleic Acids Res. 2021 Jan 8;49(D1):D1251-D1258. doi: 10.1093/nar/gkaa1006.
An updated Lnc2Cancer 3.0 (http://www.bio-bigdata.net/lnc2cancer or http://bio-bigdata.hrbmu.edu.cn/lnc2cancer) database, which includes comprehensive data on experimentally supported long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) associated with human cancers. In addition, web tools for analyzing lncRNA expression by high-throughput RNA sequencing (RNA-seq) and single-cell RNA-seq (scRNA-seq) are described. Lnc2Cancer 3.0 was updated with several new features, including (i) Increased cancer-associated lncRNA entries over the previous version. The current release includes 9254 lncRNA-cancer associations, with 2659 lncRNAs and 216 cancer subtypes. (ii) Newly adding 1049 experimentally supported circRNA-cancer associations, with 743 circRNAs and 70 cancer subtypes. (iii) Experimentally supported regulatory mechanisms of cancer-related lncRNAs and circRNAs, involving microRNAs, transcription factors (TF), genetic variants, methylation and enhancers were included. (iv) Appending experimentally supported biological functions of cancer-related lncRNAs and circRNAs including cell growth, apoptosis, autophagy, epithelial mesenchymal transformation (EMT), immunity and coding ability. (v) Experimentally supported clinical relevance of cancer-related lncRNAs and circRNAs in metastasis, recurrence, circulation, drug resistance, and prognosis was included. Additionally, two flexible online tools, including RNA-seq and scRNA-seq web tools, were developed to enable fast and customizable analysis and visualization of lncRNAs in cancers. Lnc2Cancer 3.0 is a valuable resource for elucidating the associations between lncRNA, circRNA and cancer.
一个更新的 Lnc2Cancer 3.0（http://www.bio-bigdata.net/lnc2cancer 或 http://bio-bigdata.hrbmu.edu.cn/lnc2cancer）数据库，其中包括与人类癌症相关的经过实验验证的长非编码 RNA（lncRNA）和环状 RNA（circRNA）的综合数据。此外，还描述了用于分析高通量 RNA 测序（RNA-seq）和单细胞 RNA-seq（scRNA-seq）中 lncRNA 表达的网络工具。Lnc2Cancer 3.0 进行了多项新的更新，包括：（i）比上一版本增加了与癌症相关的 lncRNA 条目。当前版本包括 9254 个 lncRNA-癌症关联，涉及 2659 个 lncRNA 和 216 种癌症亚型。（ii）新增加了 1049 个经过实验验证的 circRNA-癌症关联，涉及 743 个 circRNA 和 70 种癌症亚型。（iii）包含了癌症相关 lncRNA 和 circRNA 的实验验证的调控机制，涉及 microRNA、转录因子（TF）、遗传变异、甲基化和增强子。（iv）附加了癌症相关 lncRNA 和 circRNA 的经过实验验证的生物学功能，包括细胞生长、细胞凋亡、自噬、上皮间质转化（EMT）、免疫和编码能力。（v）包含了癌症相关 lncRNA 和 circRNA 在转移、复发、循环、耐药性和预后方面的实验验证的临床相关性。此外，还开发了两个灵活的在线工具，包括 RNA-seq 和 scRNA-seq 网络工具，用于快速和定制化分析和可视化癌症中的 lncRNA。Lnc2Cancer 3.0 是阐明 lncRNA、circRNA 和癌症之间关联的有价值的资源。
