揭示卵巢癌种族差异的线粒体决定因素。
Uncovering Mitochondrial Determinants of Racial Disparities in Ovarian Cancer.
机构信息
Department of Genetics, University of Alabama at Birmingham, Kaul Genetics Building Room, 630, 720 20th Street South, Birmingham, AL 35294, USA; Department of Molecular Endocrinology, Indian Council of Medical Research-National Institute for Research in Reproductive Health (ICMR-NIRRH), Jehangir Merwanji Street, Parel, Mumbai 400012, India.
Department of Genetics, University of Alabama at Birmingham, Kaul Genetics Building Room, 630, 720 20th Street South, Birmingham, AL 35294, USA.
出版信息
Trends Cancer. 2021 Feb;7(2):93-97. doi: 10.1016/j.trecan.2020.10.014. Epub 2020 Nov 24.
Abstract
Ovarian cancer (OC) incidence and mortality rates differ between racial groups. Mitochondrial genetic factors are now emerging as determinants of racial disparities in OC. A comprehensive understanding of the role of mitochondria in OC health disparities will help in developing novel therapeutic strategies targeting mitochondria to reduce or eliminate racial health disparities.
摘要
卵巢癌（OC）的发病率和死亡率在不同种族群体之间存在差异。线粒体遗传因素现已成为 OC 种族差异的决定因素。全面了解线粒体在 OC 健康差异中的作用，将有助于制定针对线粒体的新型治疗策略，以减少或消除种族健康差异。
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本文引用的文献
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Circulating Mitochondrial DNA is Linked to Progression and Prognosis of Epithelial Ovarian Cancer.
Transl Oncol. 2019 Sep;12(9):1213-1220. doi: 10.1016/j.tranon.2019.05.015. Epub 2019 Jul 2.
2
Signaling pathway network alterations in human ovarian cancers identified with quantitative mitochondrial proteomics.
EPMA J. 2019 Jun 8;10(2):153-172. doi: 10.1007/s13167-019-00170-5. eCollection 2019 Jun.
3
MicroRNA-663 facilitates the growth, migration and invasion of ovarian cancer cell by inhibiting TUSC2.
Biol Res. 2019 Apr 3;52(1):18. doi: 10.1186/s40659-019-0219-6.
4
ERR1 and PGC1α associated mitochondrial alterations correlate with pan-cancer disparity in African Americans.
J Clin Invest. 2019 Mar 28;129(6):2351-2356. doi: 10.1172/JCI127579.
5
Role of diets rich in omega-3 and omega-6 in the development of cancer.
Bol Med Hosp Infant Mex. 2016 Nov-Dec;73(6):446-456. doi: 10.1016/j.bmhimx.2016.11.001. Epub 2016 Nov 30.
6
Mitochondrial determinants of cancer health disparities.
Semin Cancer Biol. 2017 Dec;47:125-146. doi: 10.1016/j.semcancer.2017.05.001. Epub 2017 May 6.
7
Racial/Ethnic Disparities in Ovarian Cancer Treatment and Survival.
Clin Cancer Res. 2016 Dec 1;22(23):5909-5914. doi: 10.1158/1078-0432.CCR-16-1119. Epub 2016 Aug 12.
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