Department of Molecular Endocrinology, Indian Council of Medical Research-National Institute for Research in Reproductive and Child Health (ICMR-NIRRCH), J.M. Street, Parel, Mumbai, 400012, India.
Department of Pathology, Division of Molecular and Cellular Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, United States.
Rev Endocr Metab Disord. 2023 Apr;24(2):317-326. doi: 10.1007/s11154-023-09789-2. Epub 2023 Jan 27.
Mitochondrial DNA (mtDNA) epigenetic modifications have recently gained attention in a plethora of complex diseases, including polycystic ovary syndrome (PCOS), a common cause of infertility in women of reproductive age. Herein we discussed mtDNA epigenetic modifications and their impact on nuclear-mitochondrial interactions in general and the latest advances indicating the role of mtDNA methylation in the pathophysiology of PCOS. We highlighted epigenetic changes in nuclear-related mitochondrial genes, including nuclear transcription factors that regulate mitochondrial function and may be involved in the development of PCOS or its related traits. Additionally, therapies targeting mitochondrial epigenetics, including time-restricted eating (TRE), which has been shown to have beneficial effects by improving mitochondrial function and may be mediated by epigenetic modifications, have also been discussed. As PCOS has become a major metabolic disorder and a risk factor for obesity, cardiometabolic disorders, and diabetes, lifestyle/behavior intervention using TRE that reinforces feeding-fasting rhythms without reducing caloric intake may be a promising therapeutic strategy for attenuating the pathogenesis. Furthermore, future perspectives in the area of mitochondrial epigenetics are described.
线粒体 DNA（mtDNA）表观遗传修饰在包括多囊卵巢综合征（PCOS）在内的多种复杂疾病中受到了广泛关注，PCOS 是育龄妇女不孕的常见原因。本文讨论了 mtDNA 表观遗传修饰及其对核-线粒体相互作用的影响，以及最新研究表明 mtDNA 甲基化在 PCOS 病理生理学中的作用。我们强调了核相关线粒体基因的表观遗传变化，包括调节线粒体功能的核转录因子，这些因子可能与 PCOS 的发展或其相关特征有关。此外，还讨论了针对线粒体表观遗传的治疗方法，包括限时进食（TRE），TRE 已被证明通过改善线粒体功能具有有益的效果，并且可能通过表观遗传修饰来介导，也被认为是一种有前途的治疗策略，可以减轻发病机制。此外，还描述了线粒体表观遗传学领域的未来展望。
