先兆子痫中血管舒张性前列腺素排泄减少。
Reduced excretion of vasodilator prostaglandins in preeclampsia.
作者信息
Minuz P, Covi G, Corsato M, Probitzer P, Spiazzi L, Paluani F, Degan M, Lechi C, Lechi A
机构信息
Clinica Medica dell'Università, Policlinico di Borgo Roma, Verona, Italy.
出版信息
Agents Actions Suppl. 1987;22:175-81. doi: 10.1007/978-3-0348-9299-5_18.
The role of prostaglandin (PG) system in preeclampsia (pre-E) was investigated. Urinary excretion of PGE2,6-keto PGF1 alpha,2,3 dinor 6-keto PGF1 alpha, TxB2 and 2,3-dinor-TxB2 and kallikrein were determined in 10 normotensive pregnant women and 14 with pre-E. 6-keto PGF1 alpha and 2,3-dinor 6-keto PGF1 alpha (the main renal and extrarenal metabolites of vasodilator PGI2) and PGE2 excretion was lower in pre-E. TxB2 metabolites in urine were similar in the two groups of women. Our data are consistent with the hypothesis of an imbalance between vasodilator and vasoconstrictor PGs in pre-E.
研究了前列腺素（PG）系统在子痫前期（pre - E）中的作用。测定了10名血压正常的孕妇和14名子痫前期孕妇尿液中前列腺素E2（PGE2）、6 - 酮前列腺素F1α（6 - keto PGF1α）、2,3 - 二去甲 - 6 - 酮前列腺素F1α（2,3 dinor 6 - keto PGF1α）、血栓素B2（TxB2）、2,3 - 二去甲 - 血栓素B2（2,3 - dinor - TxB2）以及激肽释放酶的排泄情况。子痫前期患者尿液中6 - 酮前列腺素F1α和2,3 - 二去甲 - 6 - 酮前列腺素F1α（血管舒张剂前列环素I2（PGI2）的主要肾脏和肾外代谢产物）以及PGE2的排泄量较低。两组女性尿液中的TxB2代谢产物相似。我们的数据与子痫前期血管舒张性和血管收缩性PG失衡的假说一致。
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