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超声心动图在杜氏肌营养不良症基因突变携带者亚临床心功能障碍中的表现

Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers.

机构信息

Department of Internal Medicine/Cardiology, Faculty of Medicine, St. Anne's University Hospital, Masaryk University, Brno, Czech Republic.

International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic.

出版信息

Sci Rep. 2020 Nov 27;10(1):20794. doi: 10.1038/s41598-020-77882-6.

DOI:10.1038/s41598-020-77882-6
PMID:33247228
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7695725/
Abstract

To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p < 0.001, 0.08 vs. 0.09 m/s, p < 0.01 and 0.13 vs. 0.14 m/s, p = 0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p = 0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers.

摘要

评估杜氏肌营养不良症（DMD）女性携带者的亚临床心脏功能障碍。44 名经证实为 DMD 携带者的女性受试者接受了超声心动图检查，包括二尖瓣和三尖瓣环组织多普勒成像（TDI）。17 名年龄匹配的健康女性受试者作为对照组。携带者和对照组之间的二尖瓣环侧壁和间隔部以及三尖瓣环的收缩期峰值环速度（Sa）存在显著差异（0.09 与 0.11 m/s，p<0.001；0.08 与 0.09 m/s，p<0.01；0.13 与 0.14 m/s，p=0.02）。二尖瓣环间隔部的舒张早期速度（Ea）也存在差异（0.11 与 0.13 m/s，p=0.03）。即使是无症状的 DMD 女性携带者，也存在收缩功能的亚临床恶化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e61/7695725/0331229f7cde/41598_2020_77882_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e61/7695725/a8c610216231/41598_2020_77882_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e61/7695725/e56319dd7ec6/41598_2020_77882_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e61/7695725/0331229f7cde/41598_2020_77882_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e61/7695725/a8c610216231/41598_2020_77882_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e61/7695725/e56319dd7ec6/41598_2020_77882_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e61/7695725/0331229f7cde/41598_2020_77882_Fig3_HTML.jpg

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