Gurtoo Anil, Agrawal Aparna, Prakash Anupam, Kaur Ravinder, Jais Manoj, Anand Rama, Sharma Sunita, Shukla Shailaja, Singh Ritu
Director-Professor of Medicine, Lady Hardinge Medical College, New Delhi.
Professor of Medicine and Head, Dept. of Accident and Emergency, Lady Hardinge Medical College, New Delhi.
J Assoc Physicians India. 2020 Dec;68(12):43-48.
Clinical and laboratory features of COVID-19 may have regional variations. This study aimed to discern their association with severity of illness and mortality in tertiary setup of Delhi, India.
Retrospective data of hospitalised COVID-19 patients over 3 months (end March to June 2020) were evaluated for symptom profile, blood investigations and chest radiograph data and classified according to COVID-19 severity and as survivors and non-survivors.
Average age (n=182) was 46.1 years, male to female ratio 1.4:1. Fever (51.1%), cough (49.4%) and breathlessness (48.3%) were the commonest symptoms, and frequency of all the three increased with severity of COVID-19. Fever duration, leucocytosis, neutrophilia, elevated blood urea, transaminitis and higher Brixia score on chest X-ray were also more in severe COVID-19 compared to mild and moderate categories. Higher age, more comorbidities, fever, breathlessness and chest pain; longer duration of fever, leucocytosis, neutrophilia, lymphopenia, high neutrophil to lymphocyte ratio, elevated serum urea, creatinine, transaminases and hyperglycemia, and higher radiographic Brixia score were observed in non-survivors compared to survivors.
Greater prevalence of symptoms (alone and in combination) and derangements in blood biochemistry are seen in severe COVID-19 compared to mild or moderate cases, and also in non-survivors compared to survivors.
2019冠状病毒病（COVID-19）的临床和实验室特征可能存在地区差异。本研究旨在探讨其与印度德里三级医疗机构中疾病严重程度和死亡率的关联。
对2020年3月底至6月的3个月内住院的COVID-19患者的回顾性数据进行评估，分析症状特征、血液检查和胸部X光片数据，并根据COVID-19严重程度以及存活和非存活情况进行分类。
平均年龄（n = 182）为46.1岁，男女比例为1.4:1。发热（51.1%）、咳嗽（49.4%）和呼吸困难（48.3%）是最常见的症状，且这三种症状的发生率均随COVID-19严重程度的增加而升高。与轻度和中度COVID-19相比，重度COVID-19患者的发热持续时间、白细胞增多、中性粒细胞增多、血尿素升高、转氨酶升高以及胸部X光片上的布氏（Brixia）评分更高。与存活者相比，非存活者年龄更大、合并症更多、有发热、呼吸困难和胸痛；发热持续时间更长、白细胞增多、中性粒细胞增多、淋巴细胞减少、中性粒细胞与淋巴细胞比例高、血清尿素、肌酐、转氨酶升高以及血糖升高，且胸部X光片布氏评分更高。
与轻度或中度病例相比，重度COVID-19患者出现症状（单独或合并出现）的比例更高，血液生化指标紊乱更明显；与存活者相比，非存活者也是如此。
