Department of Pathology, College of Medicine, Kangwon National University, Chun-Cheon, Republic of Korea.
Department of Pathology, Yanbian Maternal and Child Health Care Hospital, Yanji, China.
Asian Pac J Cancer Prev. 2020 Nov 1;21(11):3331-3338. doi: 10.31557/APJCP.2020.21.11.3331.
Human papillomavirus (HPV) is a major cause of cervical cancer in women. The characteristics of HPV infection vary; therefore, it is necessary to identify the most common HPV genotypes among a group of subjects when introducing a vaccine program. Currently, in the Yanbian Autonomous Region, no HPV vaccinations are not provided, and no data has been reported regarding HPV rates or genotype prevalence. We aimed to find the most suitable HPV vaccine for this region and reasons why no vaccine has been introduced.
HPV genotyping of 200 Korean-Chinese women living in the Yanbian Autonomous Region who visited the hospital for annual health examination was done. We also checked main factors necessary for HPV vaccine administrative system; (1) vaccine manufacturers in China, (2) vaccine importers, (3) vaccine suppliers, (4) applicable vaccine laws, (5) the HPV vaccine permit system in Jilin Province, and (6) vaccination hospital facilities-were assessed by direct inquiry and search.
The results showed that HPV genotypes 52, 58, 16, 53, and 33 were the most common among Korean-Chinese women. These results differed from those previously reported for Korean or Chinese women. All elements necessary for introduction of HPV vaccine were prepared, but there is no HPV vaccination plan based on epidemiological investigation.
Gardasil® 9 should be the most suitable vaccine for Korean-Chinese women with HPV infection and cervical cancer in this region considering the prevalence of certain genotypes. Governments and medical institutions should take an active stance on HPV vaccination to lower the incidence of cervical cancer here. Our study may serve as an important reference for introducing a Chinese government program designed to prevent cervical cancer.
人乳头瘤病毒（HPV）是导致女性宫颈癌的主要原因。HPV 感染的特征各不相同；因此，在引入疫苗计划时，有必要确定一组研究对象中最常见的 HPV 基因型。目前，在延边朝鲜族自治州，没有提供 HPV 疫苗接种，也没有报告 HPV 率或基因型流行率的数据。我们旨在为该地区找到最合适的 HPV 疫苗，并探讨为什么没有引入疫苗的原因。
对在延边朝鲜族自治州因年度健康检查而就诊的 200 名韩裔中国女性进行 HPV 基因分型。我们还检查了 HPV 疫苗管理系统所需的主要因素；（1）中国的疫苗制造商，（2）疫苗进口商，（3）疫苗供应商，（4）适用的疫苗法律，（5）吉林省 HPV 疫苗许可制度，（6）接种医院设施，通过直接询问和搜索进行了评估。
结果显示，HPV 基因型 52、58、16、53 和 33 是韩裔中国女性中最常见的类型。这些结果与之前报道的韩国或中国女性的结果不同。引入 HPV 疫苗的所有必要因素都已准备就绪，但没有基于流行病学调查的 HPV 疫苗接种计划。
考虑到某些基因型的流行率，加卫苗 9 应该是该地区 HPV 感染和宫颈癌韩裔中国女性最适合的疫苗。政府和医疗机构应积极采取行动，以降低该地区宫颈癌的发病率。我们的研究可能为引入旨在预防宫颈癌的中国政府计划提供重要参考。
