Institute of Computational Molecular Science, Temple University, Philadelphia, Pennsylvania.
Department of Structural and Chemical Biology, CIB Margarita Salas, CSIC, Madrid, Spain.
Biophys J. 2021 Mar 16;120(6):1031-1039. doi: 10.1016/j.bpj.2020.11.020. Epub 2020 Nov 26.
Glycan-lectin recognition is vital to processes that impact human health, including viral infections. Proceeding from crystallographical evidence of case studies on adeno-, corona-, and rotaviral spike proteins, the relationship of these adhesins to mammalian galectins was examined by computational similarity assessments. Intrafamily diversity among human galectins was in the range of that to these viral surface proteins. Our findings are offered to inspire the consideration of lectin-based approaches to thwart infection by present and future viral threats, also mentioning possible implications for vaccine development.
糖基-凝集素识别对于影响人类健康的过程至关重要，包括病毒感染。从关于腺病毒、冠状病毒和轮状病毒刺突蛋白的案例研究的晶体学证据出发，通过计算相似性评估检查了这些黏附素与哺乳动物半乳凝素的关系。人类半乳凝素家族内的多样性与这些病毒表面蛋白的多样性相当。我们的研究结果旨在启发基于凝集素的方法来对抗当前和未来的病毒威胁，同时也提到了疫苗开发的可能影响。
