Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Laboratory of Brain Imaging and Neural Dynamics (BIND Lab), Chang Gung University, Taoyuan, Taiwan; Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan.
Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Psychiatry Res Neuroimaging. 2021 Jan 30;307:111227. doi: 10.1016/j.pscychresns.2020.111227. Epub 2020 Nov 17.
Previous studies have reported that patients with panic disorder (PD) exhibited an aberrant level of GABA concentration, an inhibitory neurotransmitter in the human brain. However, it remains substantially unclear whether the inhibitory function regarding the neurophysiological characteristics is altered in this disease. Sensory gating (SG) is considered as an automatic inhibitory function in the sensory cortex. In addition, brain's gamma oscillation within the sensory cortex is another index to reflect inhibitory function. Here we aimed to investigate whether the patients with PD showed altered inhibitory function in the somatosensory system, including the primary (SI) and secondary (SII) somatosensory cortices. A total of 20 healthy controls and 21 patients with PD underwent magnetoencephalographic recordings. Paired-pulse and single-pulse paradigms were used to study SG and gamma oscillations, respectively. There were no significant between-group differences in the SG function in the SI and SII. However, patients with PD demonstrated a reduced gamma power in the SI. Among the healthy individuals, strong associations between SG ratios and gamma frequency values were observed in the SI. However, such a functional relationship disappeared among the patients with PD. We suggested the reduced coupling of SG and gamma oscillation as one of the neural signatures in PD.
先前的研究报告指出，恐慌症（PD）患者的 GABA 浓度异常，GABA 是大脑中的一种抑制性神经递质。然而，目前仍不清楚这种疾病是否改变了神经生理特征的抑制功能。感觉门控（SG）被认为是感觉皮层中的一种自动抑制功能。此外，大脑感觉皮层内的伽马振荡是反映抑制功能的另一个指标。在这里，我们旨在研究 PD 患者是否在包括初级（SI）和次级（SII）体感皮层在内的体感系统中表现出抑制功能的改变。共有 20 名健康对照者和 21 名 PD 患者接受了脑磁图记录。使用成对脉冲和单脉冲范式分别研究 SG 和伽马振荡。在 SI 和 SII 中，SG 功能在两组之间没有显著差异。然而，PD 患者在 SI 中表现出伽马功率降低。在健康个体中，SI 中 SG 比值与伽马频率值之间存在很强的关联。然而，在 PD 患者中，这种功能关系消失了。我们认为，SG 和伽马振荡的耦合减少是 PD 的神经特征之一。
