Cheng Chia-Hsiung, Chan Pei-Ying S, Chen Si-Yu, Chen Yu-Han, Lu Hsinjie, Liu Chia-Yih
Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, No. 259, Wenhua 1st Rd, Taoyuan City , 333, Taiwan.
Laboratory of Brain Imaging and Neural Dynamics (BIND Lab), Chang Gung University, Taoyuan, Taiwan.
BMC Psychiatry. 2025 May 1;25(1):447. doi: 10.1186/s12888-025-06901-5.
Recent neurophysiological studies showed that patients with psychiatric disorders demonstrated abnormalities in sensorimotor functions in addition to cognitive deficits. These findings intrigued us to investigate whether trait anxiety, a persistent inclination towards being anxious in multiple contexts, would affect motor cortical functions. Event-related desynchronization (ERD) and event-related synchronization (ERS) of α and β oscillations are associated with movement execution and movement termination, respectively. However, no study has comprehensively examined the effects of trait anxiety on motor ERD and ERS. Therefore, this study aimed to determine how trait anxiety influences these motor cortical oscillations.
Twenty subjects (top 10% of the trait anxiety score distribution from 400 college students) with higher trait anxiety (HTA) and 20 subjects (bottom 10% of trait anxiety score distribution from the same sample) with lower trait anxiety (LTA) were recruited to perform a Go-Nogo task during electroencephalographic recordings. ERD and ERS of α and β oscillations to Go responses were compared between these two groups. The associations between ERD and ERS in each group were also examined.
Neither ERD nor ERS power changes were significantly different between LTA and HTA groups. Interestingly, a significant correlation between β ERD and α ERS/β ERS was found in the individuals with LTA; however, such functional coupling was not present in the individuals with HTA.
Trait anxiety negatively modulates the coupling of motor ERD and ERS.
最近的神经生理学研究表明，患有精神疾病的患者除了存在认知缺陷外，其感觉运动功能也表现异常。这些发现促使我们研究特质焦虑（即在多种情况下持续存在的焦虑倾向）是否会影响运动皮层功能。α和β振荡的事件相关去同步化（ERD）和事件相关同步化（ERS）分别与运动执行和运动终止有关。然而，尚无研究全面考察特质焦虑对运动ERD和ERS的影响。因此，本研究旨在确定特质焦虑如何影响这些运动皮层振荡。
招募了20名特质焦虑较高（HTA）的受试者（来自400名大学生中特质焦虑得分分布前10%）和20名特质焦虑较低（LTA）的受试者（来自同一样本中特质焦虑得分分布后10%），在脑电图记录期间执行一个Go-Nogo任务。比较了这两组对Go反应的α和β振荡的ERD和ERS。还检查了每组中ERD和ERS之间的关联。
LTA组和HTA组之间的ERD和ERS功率变化均无显著差异。有趣的是，在LTA个体中发现β ERD与α ERS/β ERS之间存在显著相关性；然而，在HTA个体中不存在这种功能耦合。
特质焦虑对运动ERD和ERS的耦合具有负向调节作用。
