Yalman Merve Vural, Madendag Yusuf, Sahin Erdem, Madendag Ilknur Col, Sahin Mefkure Eraslan, Acmaz Gokhan, Ozdemir Fatma, Muhtaroglu Sabahattin, Muderris Iptisam Ipek
Department of Obstetrics and Gynecology, Erciyes University Medicine Faculty, Kayseri, Turkey.
Department of Obstetrics and Gynecology, Kayseri City Hospital, Kayseri, Turkey.
Eur J Obstet Gynecol Reprod Biol. 2021 Jan;256:246-251. doi: 10.1016/j.ejogrb.2020.11.040. Epub 2020 Nov 13.
The purpose of this trial was to appraise the effects of preeclampsia and its intensity on maternal serum neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) levels during pregnancy and the post-pregnancy period.
Firstly pregnant participants (n = 156) were separated into three groups, as control, mild, and severe preeclampsia. Secondly women in post-pregnancy period (n = 368) were separated into three groups according to history of pregnancy, as healthy control, mild, and severe preeclampsia. These women were identified through the hospital data system and contacted by telephone to participate in the study.
Our study comprised 147 patients, 77 of whom were pregnant and 70 of whom were in their post-pregnancy period after the exclusion criteria had been applied. In terms of maternal serum NGAL levels, there is a significant increase in the severe preeclampsia group compared with that in the mild preeclampsia and normal pregnancy groups (p < 0.001). During the post-pregnancy period, the maternal serum NGAL levels were found significantly higher in the severe preeclampsia group than in the mild preeclampsia group and non-hypertension control group (p < 0.001). Maternal serum KIM-1 levels were found as significantly higher in the severe and mild preeclampsia groups than in the non-hypertension pregnancy group (p = 0.004). During the post-pregnancy period, maternal serum KIM-1 levels were found as similar among all post pregnant groups (p = 0.792).
Our results indicated that as the severity of preeclampsia increases, kidney damage as assessed using NGAL levels continues for a long period of time, even during the post-pregnancy period.
本试验旨在评估子痫前期及其严重程度对孕期及产后母体血清中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和肾损伤分子-1（KIM-1）水平的影响。
首先，将怀孕参与者（n = 156）分为三组，即对照组、轻度子痫前期组和重度子痫前期组。其次，将产后女性（n = 368）根据妊娠史分为三组，即健康对照组、轻度子痫前期组和重度子痫前期组。这些女性通过医院数据系统识别，并通过电话联系以参与研究。
在应用排除标准后，我们的研究纳入了147名患者，其中77名处于孕期，70名处于产后。就母体血清NGAL水平而言，重度子痫前期组与轻度子痫前期组和正常妊娠组相比显著升高（p < 0.001）。在产后期间，发现重度子痫前期组的母体血清NGAL水平显著高于轻度子痫前期组和非高血压对照组（p < 0.001）。发现重度和轻度子痫前期组的母体血清KIM-1水平显著高于非高血压妊娠组（p = 0.004）。在产后期间，发现所有产后组的母体血清KIM-1水平相似（p = 0.792）。
我们的结果表明，随着子痫前期严重程度的增加，使用NGAL水平评估的肾损伤会持续很长时间，即使在产后期间也是如此。
