细菌趋化性。细胞通量模型、参数测量、群体动态及基因操作。

Bacterial chemotaxis. Cell flux model, parameter measurement, population dynamics, and genetic manipulation.

作者信息

Lauffenburger D A, Rivero M, Kelly F, Ford R, DiRienzo J

机构信息

Department of Chemical Engineering, University of Pennsylvania, Philadelphia 19104.

出版信息

Ann N Y Acad Sci. 1987;506:281-95. doi: 10.1111/j.1749-6632.1987.tb23827.x.

DOI:10.1111/j.1749-6632.1987.tb23827.x

PMID:3324858

Abstract

In this paper, we summarized our recent efforts toward accomplishing four key goals important for control of microbial population dynamics in nonmixed systems: (1) derivation of a cell population flux model based on individual cell properties; (2) measurement of the population random motility and chemotaxis parameters appearing in this model using a simple experimental assay; (3) quantitative understanding of the effects of cell motility and chemotaxis properties on microbial population dynamics; and (4) manipulation of chemotactic responses by genetic modification.

摘要

在本文中，我们总结了近期为实现四个对非混合系统中微生物种群动态控制至关重要的关键目标所做的工作：（1）基于个体细胞特性推导细胞种群通量模型；（2）使用简单的实验测定法测量该模型中出现的种群随机运动性和趋化性参数；（3）定量理解细胞运动性和趋化性特性对微生物种群动态的影响；（4）通过基因改造操纵趋化反应。