Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Trends Cell Biol. 2021 Feb;31(2):119-129. doi: 10.1016/j.tcb.2020.11.004. Epub 2020 Nov 25.
Membrane protein organization is essential for proper cellular functioning and the result of a dynamic exchange between protein monomers, nanoscale protein clusters, and microscale higher-order structures. This exchange is affected by both lipid bilayer intrinsic factors, such as lipid rafts and tetraspanins, and extrinsic factors, such as cortical actin and galectins. Because membrane organizers act jointly like instruments in a symphony, it is challenging to define the 'key' organizers. Here, we posit, for the first time, definitions of key intrinsic and extrinsic membrane organizers. Tetraspanin nanodomains are key organizers that are often overlooked. We discuss how different key organizers can collaborate, which is important to get a full grasp of plasma membrane biology.
膜蛋白的组织对于细胞的正常功能至关重要，是蛋白质单体、纳米级蛋白簇和微尺度高级结构之间动态交换的结果。这种交换受到双层脂膜固有因素（如脂筏和四跨膜蛋白）和外在因素（如皮质肌动蛋白和半乳糖凝集素）的影响。由于膜组织者像交响乐中的乐器一样共同作用，因此很难定义“关键”的组织者。在这里，我们首次提出了关键内在和外在膜组织者的定义。四跨膜蛋白纳米域是经常被忽视的关键组织者。我们讨论了不同的关键组织者如何协作，这对于全面理解质膜生物学非常重要。
