Shen Jian, Sun Tao, Bi Yunke
College of Chemistry, Chemical and Environmental Engineering, Weifang University, Weifang 261061, China.
Key Laboratory of Smart Drug Delivery/Innovative Center for New Drug Development of Immune Inflammatory Diseases (Ministry of Education), Minhang Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.
Pharmaceutics. 2025 Jun 27;17(7):846. doi: 10.3390/pharmaceutics17070846.
Tertiary amine oxide (TAO)-containing zwitterionic polymers are a class of zwitterionic materials formed by the oxidation of tertiary amine groups. In recent years, polymers such as poly(2-(N-oxide-N,N-diethylamino)ethyl methacrylate) (OPDEA) have gained significant attention due to their unique antifouling properties, dynamic cell membrane affinity, and responsiveness to microenvironments. These characteristics have made them promising candidates in drug delivery, antibiofouling, and precision therapy. Compared to traditional polyethylene glycol (PEG), these polymers not only exhibit long-circulation properties but can also overcome biological barriers through active transport mechanisms, making them a research hotspot in the field of next-generation biomaterials. This review comprehensively summarizes the recent advancements in this field, covering aspects such as the synthesis, properties, applications, and mechanisms of TAO-containing zwitterionic polymers.
含叔胺氧化物（TAO）的两性离子聚合物是一类通过叔胺基团氧化形成的两性离子材料。近年来，诸如聚（甲基丙烯酸2-（N-氧化物-N，N-二乙氨基）乙酯）（OPDEA）等聚合物因其独特的抗污性能、动态细胞膜亲和力以及对微环境的响应性而备受关注。这些特性使其成为药物递送、抗生物污损和精准治疗领域有前景的候选材料。与传统的聚乙二醇（PEG）相比，这些聚合物不仅具有长循环特性，还能通过主动转运机制克服生物屏障，使其成为下一代生物材料领域的研究热点。本文综述全面总结了该领域的最新进展，涵盖含TAO两性离子聚合物的合成、性质、应用及作用机制等方面。
