School of Chemistry , Raymond & Beverly Sackler Faculty of Exact Sciences , Tel Aviv University, 6997801, Tel Aviv, Israel.
Center for Physics and Chemistry of Living Systems , Tel Aviv University, 6997801, Tel Aviv, Israel.
J Cell Sci. 2024 Jul 15;137(14). doi: 10.1242/jcs.261532. Epub 2024 Jul 25.
Membrane remodeling is a fundamental cellular process that is crucial for physiological functions such as signaling, membrane fusion and cell migration. Tetraspanins (TSPANs) are transmembrane proteins of central importance to membrane remodeling events. During these events, TSPANs are known to interact with themselves and other proteins and lipids; however, their mechanism of action in controlling membrane dynamics is not fully understood. Since these proteins span the membrane, membrane properties such as rigidity, curvature and tension can influence their behavior. In this Review, we summarize recent studies that explore the roles of TSPANs in membrane remodeling processes and highlight the unique structural features of TSPANs that mediate their interactions and localization. Further, we emphasize the influence of membrane curvature on TSPAN distribution and membrane domain formation and describe how these behaviors affect cellular functions. This Review provides a comprehensive perspective on the multifaceted function of TSPANs in membrane remodeling processes and can help readers to understand the intricate molecular mechanisms that govern cellular membrane dynamics.
膜重塑是一种基本的细胞过程，对于信号转导、膜融合和细胞迁移等生理功能至关重要。四跨膜蛋白（TSPANs）是对膜重塑事件至关重要的跨膜蛋白。在这些事件中，已知 TSPANs 与自身和其他蛋白质和脂质相互作用；然而，它们在控制膜动力学方面的作用机制尚不完全清楚。由于这些蛋白质贯穿膜，膜的性质，如刚性、曲率和张力，可以影响它们的行为。在这篇综述中，我们总结了最近的研究，探讨了 TSPANs 在膜重塑过程中的作用，并强调了 TSPANs 介导其相互作用和定位的独特结构特征。此外，我们强调了膜曲率对 TSPAN 分布和膜域形成的影响，并描述了这些行为如何影响细胞功能。这篇综述提供了一个全面的视角，了解 TSPANs 在膜重塑过程中的多方面功能，并帮助读者理解控制细胞膜动力学的复杂分子机制。
