Instituto de Investigación Sanitaria del Principado de Asturias, Avenida de Roma s/n, 33011, Oviedo, Spain.
Instituto de Investigación Sanitaria del Principado de Asturias, Avenida de Roma s/n, 33011, Oviedo, Spain; Centro de Investigación Biomédica en Red (CIBER)-Enfermedades Respiratorias, Calle de Melchor Fernández Almagro, 3, 28029, Madrid, Spain; Instituto Universitario de Oncología del Principado de Asturias, Calle Fernando Bongera s/n, 33006, Oviedo, Spain.
Mech Ageing Dev. 2021 Jan;193:111410. doi: 10.1016/j.mad.2020.111410. Epub 2020 Nov 26.
A wide range of insults can trigger acute injury in the lungs, which eventually may lead to respiratory failure and death of patients. Current treatment relies mainly on supportive measures and mechanical ventilation. Even so, survivors frequently develop important sequels that compromise quality of life. In the search for new approaches to prevent and treat acute lung injury, many investigations have focused on molecular and cellular pathways which could exert a pathogenic role in this disease. Herein, we review recent findings in the literature suggesting that cellular senescence could be involved in lung injury and discuss the potential use of senotherapies to prevent disease progression.
多种损伤可引发肺部急性损伤，最终可能导致患者呼吸衰竭和死亡。目前的治疗主要依赖于支持性措施和机械通气。即便如此，幸存者常出现重要的后遗症，影响生活质量。为了寻找预防和治疗急性肺损伤的新方法，许多研究集中在可能在该疾病中发挥致病作用的分子和细胞途径上。在此，我们综述文献中的最新发现，提示细胞衰老可能与肺损伤有关，并讨论了使用衰老疗法预防疾病进展的潜力。
