Escuela de Medicina, Universidad San Francisco de Quito USFQ, Quito, Ecuador; Instituto de Investigaciones en Biomedicina, Universidad San Francisco de Quito USFQ, Quito, Ecuador; Mito-Act Research Consortium, Quito, Ecuador.
Hospital de los Valles HDLV, Quito, Ecuador; Fundación Ayuda Familiar y Comunitaria AFAC, Quito, Ecuador.
Crit Rev Oncol Hematol. 2021 Jan;157:103174. doi: 10.1016/j.critrevonc.2020.103174. Epub 2020 Nov 11.
Breast cancer is one of the most frequent malignancies among women worldwide. Methods for screening and diagnosis allow health care professionals to provide personalized treatments that improve the outcome and survival. Scientists and physicians are working side-by-side to develop evidence-based guidelines and equipment to detect cancer earlier. However, the lack of comprehensive interdisciplinary information and understanding between biomedical, medical, and technology professionals makes innovation of new screening and diagnosis tools difficult. This critical review gathers, for the first time, information concerning normal breast and cancer biology, established and emerging methods for screening and diagnosis, staging and grading, molecular and genetic biomarkers. Our purpose is to address key interdisciplinary information about these methods for physicians and scientists. Only the multidisciplinary interaction and communication between scientists, health care professionals, technical experts and patients will lead to the development of better detection tools and methods for an improved screening and early diagnosis.
乳腺癌是全球女性最常见的恶性肿瘤之一。筛查和诊断方法使医疗保健专业人员能够提供个性化的治疗方案，从而改善治疗效果和生存率。科学家和医生正在携手合作，制定基于证据的指南和设备，以更早地发现癌症。然而，由于缺乏生物医学、医学和技术专业人员之间全面的跨学科信息和理解，因此难以创新新的筛查和诊断工具。这篇重要的综述首次汇集了有关正常乳房和癌症生物学、已确立和新兴的筛查和诊断方法、分期和分级、分子和遗传生物标志物的信息。我们的目的是为医生和科学家提供这些方法的关键跨学科信息。只有科学家、医疗保健专业人员、技术专家和患者之间的多学科互动和交流，才能开发出更好的检测工具和方法，从而改善筛查和早期诊断。
