Safai B, Lynfield R, Lowenthal D A, Koziner B
Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Anticancer Res. 1987 Sep-Oct;7(5B):1055-67.
The spectrum of neoplastic disease seen in patients with the acquired immune deficiency syndrome (AIDS) is similar to that seen in several congenital and iatrogenic immunodeficiency states and provides a human model for studying neoplastic transformation in the immune compromised host. High grade lymphoid neoplasia, particularly of the central nervous system (CNS), as well as a virulent form of Kaposi's sarcoma (KS) and several types of squamous cell carcinomas, are appearing at an alarming rate in patients with AIDS. There is substantial serologic, pathologic and molecular evidence linking cytomegalovirus (CMV) to KS and Epstein-Barr virus (EBV) to squamous cell carcinoma and high-grade B-cell non-Hodgkin's lymphoma (NHL). The human T-cell lymphotropic virus type III/lymphadenopathy associated virus (HTLV-III/LAV) may be responsible for the permissive immune deficient state allowing for opportunistic neoplasia and the aggressive biologic behavior and atypical anatomic distribution these neoplasms exhibit. The clinical features as well as potential etiopathogenetic mechanisms of these malignancies are reviewed.
获得性免疫缺陷综合征（AIDS）患者中所见的肿瘤性疾病谱与几种先天性和医源性免疫缺陷状态下所见的相似，并为研究免疫受损宿主中的肿瘤转化提供了一个人类模型。高级别淋巴样肿瘤，特别是中枢神经系统（CNS）的肿瘤，以及一种恶性形式的卡波西肉瘤（KS）和几种类型的鳞状细胞癌，在AIDS患者中出现的速度惊人。有大量血清学、病理学和分子证据将巨细胞病毒（CMV）与KS联系起来，将爱泼斯坦-巴尔病毒（EBV）与鳞状细胞癌和高级别B细胞非霍奇金淋巴瘤（NHL）联系起来。人类嗜T细胞病毒III型/淋巴结病相关病毒（HTLV-III/LAV）可能是导致允许机会性肿瘤形成以及这些肿瘤所表现出的侵袭性生物学行为和非典型解剖分布的免疫缺陷状态的原因。本文综述了这些恶性肿瘤的临床特征以及潜在的病因发病机制。
