Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Research Centre for Generational Health and Ageing, University of Newcastle, New South Wales, Australia.
J Gerontol A Biol Sci Med Sci. 2021 Jun 14;76(7):1265-1272. doi: 10.1093/gerona/glaa290.
Smoking and obesity are 2 modifiable risk factors for disability. We examine the impact of smoking and obesity on disability-free life expectancy (DFLE) at older ages, using 2 levels of disability.
We used the DYNOPTA dataset, derived by harmonizing and pooling risk factors and disability outcomes from 5 Australian longitudinal aging studies. We defined mobility disability as inability to walk 1 km, and more severe (activities of daily living [ADL]) disability by the inability to dress or bathe. Mortality data for the analytic sample (N = 20 401; 81.2% women) were obtained from Government Records via data linkage. We estimated sex-specific total life expectancy, DFLE, and years spent with disability by Interpolated Markov Chain (IMaCh) software for each combination of smoking (never vs ever), obesity (body mass index ≥30 vs 18.5 to <30), and education (left school age 14 or younger vs age 15 or older).
Compared to those without either risk factor, high educated nonobese smokers at age 65 lived shorter lives (men and women: 2.5 years) and fewer years free of mobility disability (men: 2.1 years; women: 2.0 years), with similar results for ADL disability. Obesity had the largest effect on mobility disability in women; high educated obese nonsmoking women lived 1.3 years less than nonsmoking, not obese women but had 5.1 years fewer free of mobility disability and 3.2 fewer free of ADL disability. Differences between risk factor groups were similar for the low educated.
Our findings suggest eliminating obesity would lead to an absolute reduction of disability, particularly in women.
吸烟和肥胖是 2 种可改变的残疾风险因素。我们使用 2 种残疾水平来检查吸烟和肥胖对老年人无残疾预期寿命(DFLE)的影响。
我们使用 DYNOPTA 数据集,该数据集由 5 项澳大利亚纵向老龄化研究中的风险因素和残疾结果进行调和与汇集而得。我们将行动障碍定义为无法行走 1 公里,将更严重的(日常生活活动[ADL])障碍定义为无法穿衣或洗澡。通过数据链接,从政府记录中获取分析样本(N=20401;81.2%为女性)的死亡数据。我们使用Interpolated Markov Chain(IMaCh)软件估算了每个吸烟(从不吸烟与吸烟)、肥胖(体重指数≥30 与 18.5 至<30)和教育(14 岁或以下离开学校与 15 岁或以上离开学校)组合的男性和女性的特定总预期寿命、DFLE 以及残疾年限。
与没有任何风险因素的人相比,65 岁时受教育程度高但不肥胖的吸烟者寿命较短(男性和女性:2.5 年),无行动障碍的年限也较少(男性:2.1 年;女性:2.0 年),ADL 残疾的结果相似。肥胖对女性的行动障碍影响最大;受教育程度高但肥胖的不吸烟者比不吸烟且不肥胖的女性寿命短 1.3 年,但无行动障碍的年限少 5.1 年,无 ADL 残疾的年限少 3.2 年。低教育程度人群中,风险因素组之间的差异相似。
我们的研究结果表明,消除肥胖将导致残疾的绝对减少,特别是在女性中。