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前路椎体束缚术治疗特发性脊柱侧凸的安全性和有效性。

Safety and efficacy of anterior vertebral body tethering in the treatment of idiopathic scoliosis.

机构信息

British Columbia Children's Hospital, Vancouver, British Columbia, Canada.

San Diego Spine Foundation, San Diego, California, USA.

出版信息

Bone Joint J. 2020 Dec;102-B(12):1703-1708. doi: 10.1302/0301-620X.102B12.BJJ-2020-0426.R1.

Abstract

AIMS

Spinal fusion remains the gold standard in the treatment of idiopathic scoliosis. However, anterior vertebral body tethering (AVBT) is gaining widespread interest, despite the limited data on its efficacy. The aim of our study was to determine the clinical efficacy of AVBT in skeletally immature patients with idiopathic scoliosis.

METHODS

All consecutive skeletally immature patients with idiopathic scoliosis treated with AVBT enrolled in a longitudinal, multicentre, prospective database between 2013 and 2016 were analyzed. All patients were treated by one of two surgeons working at two independent centres. Data were collected prospectively in a multicentre database and supplemented retrospectively where necessary. Patients with a minimum follow-up of two years were included in the analysis. Clinical success was set a priori as a major coronal Cobb angle of < 35° at the most recent follow-up.

RESULTS

A total of 57 patients were included in the study. Their mean age was 12.7 years (SD 1.5; 8.2 to 16.7), with 95% being female. The mean preoperative Sanders score and Risser grade was 3.3 (SD 1.2), and 0.05 (0 to 3), respectively. The majority were thoracic tethers (96.5%) and the mean follow-up was 40.4 months (SD 9.3). The mean preoperative major curve of 51° (SD 10.9°; 31° to 81°) was significantly improved to a mean of 24.6° (SD 11.8°; 0° to 57°) at the first postoperative visit (45.6% (SD 17.6%; 7% to 107%); p < 0.001)) with further significant correction to a mean of 16.3° (SD 12.8°; -12 to 55; p < 0.001) at one year and a significant correction to a mean of 23° (SD 15.4°; -18° to 57°) at the final follow-up (42.9% (-16% to 147%); p < 0.001). Clinical success was achieved in 44 patients (77%). Most patients reached skeletal maturity, with a mean Risser score of 4.3 (SD 1.02), at final follow-up. The complication rate was 28.1% with a 15.8% rate of unplanned revision procedures.

CONCLUSION

AVBT is associated with satisfactory correction of deformity and an acceptable complication rate when used in skeletally immature patients with idiopathic scoliosis. Improved patient selection and better implant technology may improve the 15.8% rate of revision surgery in these patients. Further scrutiny of the true effectiveness and long-term risks of this technique remains critical. Cite this article: 2020;102-B(12):1703-1708.

摘要

目的

脊柱融合仍然是特发性脊柱侧凸治疗的金标准。然而,尽管关于其疗效的数据有限,前路椎体束缚术(AVBT)仍越来越受到关注。我们研究的目的是确定 AVBT 在骨骼未成熟的特发性脊柱侧凸患者中的临床疗效。

方法

2013 年至 2016 年期间,我们分析了在纵向、多中心、前瞻性数据库中连续接受 AVBT 治疗的所有骨骼未成熟的特发性脊柱侧凸患者。所有患者均由在两个独立中心工作的两位外科医生之一进行治疗。数据在多中心数据库中进行前瞻性收集,并在必要时进行回顾性补充。至少随访两年的患者纳入分析。临床成功被预先设定为最近随访时主要冠状 Cobb 角<35°。

结果

共有 57 例患者纳入研究。他们的平均年龄为 12.7 岁(标准差 1.5;8.2 至 16.7),95%为女性。术前 Sanders 评分和 Risser 分级中位数分别为 3.3(标准差 1.2)和 0.05(0 至 3)。大多数为胸段束缚(96.5%),平均随访时间为 40.4 个月(标准差 9.3)。术前主要弯曲度为 51°(标准差 10.9°;31°至 81°),在术后第一次就诊时显著改善至平均 24.6°(标准差 11.8°;0°至 57°)(45.6%(标准差 17.6%;7%至 107%);p<0.001),在一年时进一步显著矫正至平均 16.3°(标准差 12.8°;-12 至 55;p<0.001),在最终随访时显著矫正至平均 23°(标准差 15.4°;-18°至 57°)(42.9%(-16%至 147%);p<0.001)。44 例患者(77%)达到临床成功。大多数患者在最终随访时达到骨骼成熟,平均 Risser 评分为 4.3(标准差 1.02)。并发症发生率为 28.1%,计划外翻修手术率为 15.8%。

结论

在骨骼未成熟的特发性脊柱侧凸患者中,AVBT 与畸形的满意矫正和可接受的并发症发生率相关。通过改进患者选择和更好的植入物技术,可能会降低这些患者 15.8%的翻修手术率。对该技术的真正有效性和长期风险的进一步审查仍然至关重要。

引用本文

2020;102-B(12):1703-1708。

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