Zhang Hong, Lin Fengping, Zhao Jiuhua, Wang Zhengchao
Provincial Key Laboratory for Developmental Biology and Neurosciences, Provincial University Key Laboratory of Sport and Health Science, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, China.
West Anhui Health Vocational College, Lu'an, China.
Front Physiol. 2020 Nov 5;11:595086. doi: 10.3389/fphys.2020.595086. eCollection 2020.
In mammals, developing ovarian follicles transform from primordial follicles to primary follicles, secondary follicles, and mature follicles, accompanied by changes in follicular secretory functions. FoxO3a is a member of the forkhead transcription factor family (FoxO), which plays an important role in the cell cycle, DNA damage repair, apoptosis, oxidative stress, and energy metabolism. Recent studies have shown that FOXO3a is involved in the physiological regulation of follicular development and pathological progression of related ovarian diseases, which will provide useful concepts and strategies for retarding ovarian aging, prolonging the ovarian life span, and treating ovarian diseases. Therefore, the regulation of FOXO3a expression, as well as the physiological contribution during ovarian follicular development are detailed in this paper, presenting an important reference for the further study of ovarian biology.
在哺乳动物中，发育中的卵巢卵泡从原始卵泡转变为初级卵泡、次级卵泡和成熟卵泡，同时伴随着卵泡分泌功能的变化。FoxO3a是叉头转录因子家族（FoxO）的成员，在细胞周期、DNA损伤修复、细胞凋亡、氧化应激和能量代谢中起重要作用。最近的研究表明，FOXO3a参与卵泡发育的生理调节和相关卵巢疾病的病理进展，这将为延缓卵巢衰老、延长卵巢寿命和治疗卵巢疾病提供有用的概念和策略。因此，本文详细阐述了FOXO3a表达的调节以及在卵巢卵泡发育过程中的生理作用，为进一步研究卵巢生物学提供了重要参考。
