Manansala Michael, Ascoli Christian, Alburquerque Ana Goico, Perkins David, Mirsaedi Mehdi, Finn Patricia, Sweiss Nadera J
Department of Internal Medicine, University of Illinois at Chicago, Chicago, IL, United States.
Miller School of Medicine, University of Miami, Miami, FL, United States.
Front Med (Lausanne). 2020 Nov 4;7:588527. doi: 10.3389/fmed.2020.588527. eCollection 2020.
Data on the clinical presentation and outcomes of sarcoidosis patients with coronavirus disease 19 (COVID-19) are scarce. In this case series, we identified 5 out of 238 sarcoidosis patients who are enrolled in an ongoing longitudinal observational study who developed COVID-19 during the study period and follow their clinical course. Four patients recovered completely, whereas one patient expired during hospital admission. Our preliminary experience suggests that African American patients with chronic sarcoidosis treated with disease-modifying anti-rheumatic drugs (DMARDs) or anti-tumor necrosis factor (TNF) therapy do not seem to be at increased risk of respiratory or life-threatening complications from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared with the general population, although at the present time, we advocate for maintaining a high level of vigilance and strict follow-up in this patient population.
关于结节病患者感染冠状病毒病19(COVID-19)的临床表现和预后的数据很少。在这个病例系列中,我们从238名参与一项正在进行的纵向观察性研究的结节病患者中,确定了5名在研究期间感染COVID-19的患者,并跟踪他们的临床病程。4名患者完全康复,而1名患者在住院期间死亡。我们的初步经验表明,与普通人群相比,接受改善病情抗风湿药物(DMARDs)或抗肿瘤坏死因子(TNF)治疗的慢性结节病非裔美国患者,似乎不会增加感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2)后出现呼吸或危及生命并发症的风险,尽管目前我们主张对这一患者群体保持高度警惕并进行严格随访。