Manansala Michael, Chopra Amit, Baughman Robert P, Novak Richard, Lower Elyse E, Culver Daniel A, Korsten Peter, Drake Wonder P, Judson Marc A, Sweiss Nadera
Department of Medicine, Academic Internal Medicine, University of Illinois at Chicago, Chicago, IL, United States.
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Albany Medical College, Albany, NY, United States.
Front Med (Lausanne). 2021 Apr 30;8:672028. doi: 10.3389/fmed.2021.672028. eCollection 2021.
Sarcoidosis is an immune mediated chronic inflammatory disorder that is best characterized by non-caseating granulomas found in one or more affected organs. The COVID-19 pandemic poses a challenge for clinicians caring for sarcoidosis patients who may be at increased risk of infection compared to the general population. With the recent availability of COVID-19 vaccines, it is expected that clinicians raise questions regarding efficacy and safety in sarcoidosis. However, studies examining safety and efficacy of vaccines in sarcoidosis are lacking. In this review, we examine the current literature regarding vaccination in immunocompromised populations and apply them to sarcoidosis patients. The available literature suggests that vaccines are safe and effective in patients with autoimmune disorders and in those taking immunosuppressive medications. We strongly recommend the administration of COVID-19 vaccines in patients with sarcoidosis. We also present a clinical decision algorithm to provide guidance on vaccination of sarcoidosis patients against COVID-19.
结节病是一种免疫介导的慢性炎症性疾病，其最佳特征是在一个或多个受影响器官中发现非干酪样肉芽肿。与普通人群相比，COVID-19大流行给照顾结节病患者的临床医生带来了挑战，因为这些患者可能有更高的感染风险。随着COVID-19疫苗最近开始可用，预计临床医生会对结节病患者中疫苗的疗效和安全性提出问题。然而，缺乏关于疫苗在结节病中的安全性和疗效的研究。在这篇综述中，我们研究了目前关于免疫功能低下人群接种疫苗的文献，并将其应用于结节病患者。现有文献表明，疫苗在自身免疫性疾病患者和服用免疫抑制药物的患者中是安全有效的。我们强烈建议结节病患者接种COVID-19疫苗。我们还提出了一种临床决策算法，为结节病患者接种COVID-19疫苗提供指导。
