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鼠内脏利什曼病中的炎症细胞表达一种树突状细胞标志物。

Inflammatory cells in murine visceral leishmaniasis express a dendritic cell marker.

作者信息

Kaye P M

机构信息

Department of Tropical Hygiene, London School of Hygiene and Tropical Medicine, UK.

出版信息

Clin Exp Immunol. 1987 Dec;70(3):515-9.

PMID:3325201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1542190/
Abstract

Immunohistological studies of the murine liver following Leishmania donovani infection have been performed. We describe here the identification of cells expressing a recently defined dendritic cell marker, as detected by monoclonal antibody NLDC 145. Such cells are numerous in the developing inflammatory foci but are not detected individually at any other site in the infected liver. This finding suggests that mature tissue DC are not recruited during infection and that expression of this antigen is under precise microenvironmental control.

摘要

已经对杜氏利什曼原虫感染后的小鼠肝脏进行了免疫组织学研究。我们在此描述通过单克隆抗体NLDC 145检测到的表达最近定义的树突状细胞标志物的细胞的鉴定。这些细胞在正在形成的炎症灶中大量存在，但在感染肝脏的任何其他部位均未单独检测到。这一发现表明，感染期间未募集成熟的组织树突状细胞，并且该抗原的表达受到精确的微环境控制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a97d/1542190/b549218fbbcd/clinexpimmunol00105-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a97d/1542190/b549218fbbcd/clinexpimmunol00105-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a97d/1542190/b549218fbbcd/clinexpimmunol00105-0030-a.jpg

相似文献

1
Inflammatory cells in murine visceral leishmaniasis express a dendritic cell marker.鼠内脏利什曼病中的炎症细胞表达一种树突状细胞标志物。
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2
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3
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本文引用的文献

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F4/80, a monoclonal antibody directed specifically against the mouse macrophage.F4/80，一种特异性针对小鼠巨噬细胞的单克隆抗体。
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Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control.
Differences in Lsh gene control over systemic Leishmania major and Leishmania donovani or Leishmania mexicana mexicana infections are caused by differential targeting to infiltrating and resident liver macrophage populations.
Lsh基因对系统性硕大利什曼原虫、杜氏利什曼原虫或墨西哥利什曼原虫感染控制的差异，是由其对浸润性和驻留性肝巨噬细胞群体的不同靶向作用所致。
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4
Acquisition of cell-mediated immunity to Leishmania. II. LSH gene regulation of accessory cell function.获得针对利什曼原虫的细胞介导免疫。II. 辅助细胞功能的LSH基因调控。
Immunology. 1988 Sep;65(1):17-22.
树突状细胞在Ir基因控制下诱导T细胞对合成抗原的增殖。
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4
Dendritic cells in the immune response: characteristics and recommended nomenclature (A report from the Reticuloendothelial Society Committee on Nomenclature).免疫反应中的树突状细胞：特征与推荐命名法（网状内皮细胞学会命名委员会报告）
J Reticuloendothel Soc. 1982 May;31(5):371-80.
5
Polymorphic expression of a neutrophil differentiation antigen revealed by monoclonal antibody 7/4.单克隆抗体7/4揭示的中性粒细胞分化抗原的多态性表达。
Immunogenetics. 1983;18(3):229-39. doi: 10.1007/BF00952962.
6
Functional significance of the regulation of macrophage Ia expression.巨噬细胞Ia表达调控的功能意义。
Eur J Immunol. 1984 Feb;14(2):138-43. doi: 10.1002/eji.1830140207.
7
The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs.通过抗原F4/80免疫组织化学定位确定的小鼠单核吞噬细胞系统。淋巴和造血器官中巨噬细胞、朗格汉斯细胞、网状细胞和树突状细胞之间的关系。
J Exp Med. 1983 Nov 1;158(5):1522-36. doi: 10.1084/jem.158.5.1522.
8
Antigen-presenting function of the macrophage.巨噬细胞的抗原呈递功能。
Annu Rev Immunol. 1984;2:395-428. doi: 10.1146/annurev.iy.02.040184.002143.
9
A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.由I-A和I-E亚区编码的Ia抗原上的一个共享同种异体抗原决定簇：I区基因重复的证据。
J Immunol. 1981 Dec;127(6):2488-95.
10
Dendritic cells: features and functions.树突状细胞：特征与功能
Immunol Rev. 1980;53:127-47. doi: 10.1111/j.1600-065x.1980.tb01042.x.