Kaye P M, Patel N K, Blackwell J M
Department of Tropical Hygiene, London School of Hygiene and Tropical Medicine, U.K.
Immunology. 1988 Sep;65(1):17-22.
The macrophage natural resistance gene. Lsh, regulates the ability of a selective population of tissue macrophages to control intracellular multiplication of Leishmania donovani by a T-cell independent mechanism. We show here, using mice congenic for Lsh, that this gene also contributes to the acquisition of T-cell-mediated immunity. Whereas both resistant and susceptible mice generate equivalent primary T-cell responses to infection, resistant mice show a rapid increase in accessory cell activity, allowing for greater subsequent T-cell expansion. This change in accessory cell function correlates with increased class II antigen expression relative to susceptible mice, both in vivo during early infection and in vitro in response to induction by interferon-gamma (IFN-gamma). Differences in vitro were independent of, but differentially affected by, amastigote infection.
巨噬细胞天然抗性基因Lsh通过一种不依赖T细胞的机制，调节特定组织巨噬细胞群体控制杜氏利什曼原虫细胞内增殖的能力。我们在此利用Lsh基因同源的小鼠表明，该基因也有助于获得T细胞介导的免疫。虽然抗性和易感小鼠对感染产生的初始T细胞反应相当，但抗性小鼠的辅助细胞活性迅速增加，从而使随后的T细胞有更大程度的扩增。辅助细胞功能的这种变化与早期感染期间体内以及体外经γ干扰素（IFN-γ）诱导后相比易感小鼠II类抗原表达增加相关。体外差异与无鞭毛体感染无关，但受其不同影响。
