Department of Cardiology, Faculty of Medicine, Koç University Hospital; İstanbul-Turkey.
Department of Cardiology, Bakırköy Dr. Sadi Konuk Training and Research Hospital; İstanbul-Turkey.
Anatol J Cardiol. 2020 Dec;24(6):397-404. doi: 10.14744/AnatolJCardiol.2020.44388.
Microvascular angina (MVA) is a coronary microcirculation disease. Research on microcirculatory dysfunction has revealed several biomarkers involved in the etiopathogenesis of MVA. Platelet-derived growth factor receptor β (PDGFR-β) and brain-derived neurotrophic factor (BDNF) are 2 biomarkers associated with microcirculation, particularly pericytes function. The aim of this study was to investigate the role of PDGFR-β and BDNF in MVA.
Ninety-one patients (median age, 56 y; age range, 40-79 y; 36 men) with MVA and 61 control group subjects (median age, 52 y; age range, 38-76 y; 29 men) were included in the study. Serum concentrations of PDGFR-β and BDNF were measured with commercially available enzyme-linked immunosorbent assay kits.
PDGFR-β [2.82 ng/ml; interquartile range (IQR), 0.57-7.79 ng/ml vs. 2.27 ng/ml; IQR, 0.41-7.16 ng/ml; p<0.0005] and BDNF (2.41 ng/ml; IQR, 0.97-7.97 ng/ml vs. 1.92 ng/ml; IQR, 1.07-6.67 ng/ml; p=0.023) concentrations were significantly higher in patients with MVA compared with the controls. PDGFR-β correlated positively with age (r=0.26, p=0.001), low-density lipoprotein (r=0.18; p=0.02), and BDNF (r=0.47; p<0.001), and BDNF showed a significant positive correlation with age (r=0.20; p=0.01). In binary logistic regression analysis, high-sensitivity C-reactive protein, uric acid, and PDGFR-β values were found to be independent predictors of MVA.
MVA is associated with higher PDGFR-β and BDNF levels. This association may indicate an abnormality in microvascular function. Future studies are required to determine the role of these biomarkers in the pathogenesis of MVA.
微血管性心绞痛（MVA）是一种冠状动脉微循环疾病。对微循环功能障碍的研究揭示了几种与 MVA 发病机制相关的生物标志物。血小板衍生生长因子受体 β（PDGFR-β）和脑源性神经营养因子（BDNF）是与微循环相关的 2 种生物标志物，尤其是与周细胞功能相关。本研究旨在探讨 PDGFR-β和 BDNF 在 MVA 中的作用。
本研究纳入了 91 例 MVA 患者（中位年龄 56 岁；年龄范围 40-79 岁；36 名男性）和 61 例对照组受试者（中位年龄 52 岁；年龄范围 38-76 岁；29 名男性）。使用商业上可获得的酶联免疫吸附测定试剂盒测量血清 PDGFR-β 和 BDNF 浓度。
MVA 患者的 PDGFR-β[2.82ng/ml；四分位距（IQR），0.57-7.79ng/ml 比 2.27ng/ml；IQR，0.41-7.16ng/ml；p<0.0005]和 BDNF（2.41ng/ml；IQR，0.97-7.97ng/ml 比 1.92ng/ml；IQR，1.07-6.67ng/ml；p=0.023）浓度明显高于对照组。PDGFR-β与年龄（r=0.26，p=0.001）、低密度脂蛋白（r=0.18；p=0.02）和 BDNF（r=0.47；p<0.001）呈正相关，BDNF 与年龄呈显著正相关（r=0.20；p=0.01）。在二元逻辑回归分析中，发现高敏 C 反应蛋白、尿酸和 PDGFR-β 值是 MVA 的独立预测因子。
MVA 与较高的 PDGFR-β 和 BDNF 水平相关。这种关联可能表明微血管功能异常。需要进一步研究以确定这些生物标志物在 MVA 发病机制中的作用。
