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海洋海绵（Dysidea avara）的化学成分分析及其在咪喹莫特诱导银屑病皮肤模型中的抗银屑病活性。

Chemical profiling and anti-psoriatic activity of marine sponge (Dysidea avara) in induced imiquimod-psoriasis-skin model.

机构信息

Marine Pharmaceutical Science Research Center, Department of Pharmacognosy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Nanotechnology Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

出版信息

PLoS One. 2020 Nov 30;15(11):e0241582. doi: 10.1371/journal.pone.0241582. eCollection 2020.

DOI:10.1371/journal.pone.0241582
PMID:33253155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7703918/
Abstract

Since Marine sponge Dysidea avara is regarded as a source of anti-inflammatory compounds, we decided to evaluate its potential anti-psoriatic activity in a psoriasis Imiquimod-induced in the mouse model. Psoriatic mice were treated with three different methanolic extracts of Dysidea avara compared with betamethasone-treated mice in in- vivo studies. Clinical skin severity was assessed with the psoriasis area index (PASI), whilst ELISA detected the expression of TNF-α, IL-17A, and IL-22. Dysidea avara activity was studied by employing GC-MS (to distinguish compounds), HPTLC (for skin permeation and accumulation), and SEA DOCK to predict single compound potential anti-inflammatory activity. After 7 days of treatment, mice treated with Dysidea avara displayed a dose-dependent, statistically significant improvement compared to controls (p< 0.001). In line with the clinical results, ELISA revealed a statistically significant decrease in IL-22, IL-17A, and TNF-α after treatment; the same SEA DOCK analysis suggests a possible anti-psoriatic activity of the extracts.

摘要

由于海绵 Dysidea avara 被认为是抗炎化合物的来源，我们决定在咪喹莫特诱导的小鼠银屑病模型中评估其潜在的抗银屑病活性。在体内研究中，将三种不同的海绵 Dysidea avara 甲醇提取物与倍他米松治疗的小鼠进行比较。通过银屑病面积指数 (PASI) 评估临床皮肤严重程度，而 ELISA 检测 TNF-α、IL-17A 和 IL-22 的表达。通过 GC-MS（区分化合物）、HPTLC（用于皮肤渗透和积累）和 SEA DOCK 研究海绵 Dysidea avara 的活性，以预测单一化合物的潜在抗炎活性。经过 7 天的治疗，与对照组相比，用海绵 Dysidea avara 治疗的小鼠显示出剂量依赖性、统计学显著改善（p<0.001）。与临床结果一致，ELISA 显示治疗后 IL-22、IL-17A 和 TNF-α 均呈统计学显著下降；SEA DOCK 分析同样表明提取物具有可能的抗银屑病活性。

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