Department of Oncology-ONCOMED Outpatient Unit, Ciprian Porumbescu Street, No. 59, 300239 Timisoara, Romania.
Department of Oncology-ONCOHELP Hospital Timisoara, Ciprian Porumbescu Street, No. 59, 300239 Timisoara, Romania.
Int J Environ Res Public Health. 2020 Nov 24;17(23):8722. doi: 10.3390/ijerph17238722.
This study focused on the characteristics of postmenopausal breast cancer in the population of southeastern Europe. This retrospective study explored the clinical, epidemiological, and molecular characteristics of women with postmenopausal breast cancer.
A retrospective cohort study was performed on 721 postmenopausal breast cancer patients selected from the database of our institution. The data collected consisted of age, living environment, location of the breast tumor, stage of the disease, and molecular sub-type. Patient characteristics were collected based on a systematic chart audit from medical records. The data were analyzed using SPSS 20.0 and Pearson analysis.
The most frequent age range for breast cancer diagnosis was 51 to 70 years old. Most of the patients (80.7%) came from an urban environment. The vast majority of patients were initially diagnosed in stage II (40.3%) and III (30.3%). The most frequent molecular sub-types were luminal B (39%) and luminal A (35.4%). Almost half of the breast tumors were located in the upper outer quadrant (48.8%).
The results of this study describe the profile of patients in southeastern Europe within our institution diagnosed with postmenopausal breast cancer. In our study, patients were first diagnosed with more advanced stages of breast cancer compared with other European countries.
本研究关注的是东南欧绝经后乳腺癌的特征。本回顾性研究探讨了绝经后乳腺癌女性的临床、流行病学和分子特征。
对我院数据库中 721 例绝经后乳腺癌患者进行回顾性队列研究。收集的数据包括年龄、居住环境、乳房肿瘤位置、疾病分期和分子亚型。根据病历的系统图表审核收集患者特征。使用 SPSS 20.0 和 Pearson 分析对数据进行分析。
诊断乳腺癌最常见的年龄范围为 51 至 70 岁。大多数患者（80.7%）来自城市环境。大多数患者最初被诊断为 II 期（40.3%）和 III 期（30.3%）。最常见的分子亚型是 luminal B（39%）和 luminal A（35.4%）。将近一半的乳房肿瘤位于外上象限（48.8%）。
本研究结果描述了本机构诊断为绝经后乳腺癌的东南欧患者的特征。在我们的研究中，与其他欧洲国家相比，患者首次被诊断为更晚期的乳腺癌。
