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Magnetic Particles for CTC Enrichment.

作者信息

Liu Peng, Jonkheijm Pascal, Terstappen Leon W M M, Stevens Michiel

机构信息

Department of Medical Cell BioPhysics, University of Twente, 7522 NB Enschede, The Netherlnds.

Department of Molecular Nanofabrication, University of Twente, 7522 NB Enschede, The Netherlands.

出版信息

Cancers (Basel). 2020 Nov 26;12(12):3525. doi: 10.3390/cancers12123525.

DOI:10.3390/cancers12123525
PMID:33255978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7760229/
Abstract

Here, we review the characteristics and synthesis of magnetic nanoparticles (MNPs) and place these in the context of their usage in the immunomagnetic enrichment of Circulating Tumor Cells (CTCs). The importance of the different characteristics is explained, the need for a very specific enrichment is emphasized and different (commercial) magnetic separation techniques are shown. As the specificity of an MNP is in a large part dependent on the antibody coated onto the particle, different strategies in the coupling of specific antibodies as well as an overview of the available antibodies is given.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/e4071cf36d48/cancers-12-03525-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/e44fdc7f1ee1/cancers-12-03525-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/55989e50147f/cancers-12-03525-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/0ca74f7ec913/cancers-12-03525-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/724297e93131/cancers-12-03525-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/723c270940d3/cancers-12-03525-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/3833324b3b87/cancers-12-03525-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/e4071cf36d48/cancers-12-03525-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/e44fdc7f1ee1/cancers-12-03525-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/55989e50147f/cancers-12-03525-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/0ca74f7ec913/cancers-12-03525-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/724297e93131/cancers-12-03525-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/723c270940d3/cancers-12-03525-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/3833324b3b87/cancers-12-03525-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b99/7760229/e4071cf36d48/cancers-12-03525-g007.jpg

相似文献

[1]
Magnetic Particles for CTC Enrichment.

Cancers (Basel). 2020-11-26

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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[1]
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[2]
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[3]
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Front Oncol. 2025-4-7

[4]
Magnetic-Plasmonic Core-Shell Nanoparticles: Properties, Synthesis and Applications for Cancer Detection and Treatment.

Nanomaterials (Basel). 2025-2-10

[5]
Circulating Tumor Cells in Cancer Diagnosis, Therapy, and Theranostics Applications: An Overview of Emerging Materials and Technologies.

Curr Pharm Des. 2025

[6]
Roadmap on magnetic nanoparticles in nanomedicine.

Nanotechnology. 2024-11-5

[7]
Nanoparticles as a novel key driver for the isolation and detection of circulating tumour cells.

Sci Rep. 2024-9-29

[8]
A Novel Size-Based Centrifugal Microfluidic Design to Enrich and Magnetically Isolate Circulating Tumor Cells from Blood Cells through Biocompatible Magnetite-Arginine Nanoparticles.

Sensors (Basel). 2024-9-18

[9]
Co-crosslinking strategy for dual functionalization of small magnetic nanoparticles with redox probes and biological probes.

Mikrochim Acta. 2024-7-5

[10]
Advances in the role of circulating tumor cell heterogeneity in metastatic small cell lung cancer.

Cancer Innov. 2023-11-22

本文引用的文献

[1]
MRBLES 2.0: High-throughput generation of chemically functionalized spectrally and magnetically encoded hydrogel beads using a simple single-layer microfluidic device.

Microsyst Nanoeng. 2020-11-30

[2]
Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells.

Proc Natl Acad Sci U S A. 2020-7-8

[3]
A SERS-colorimetric dual-mode aptasensor for the detection of cancer biomarker MUC1.

Anal Bioanal Chem. 2020-9

[4]
A Multifunctional Platform for the Capture, Release, And Enumeration of Circulating Tumor Cells Based on Aptamer Binding, Nicking Endonuclease-Assisted Amplification, And Inductively Coupled Plasma Mass Spectrometry Detection.

Anal Chem. 2020-8-4

[5]
Magnetic-Based Enrichment of Rare Cells from High Concentrated Blood Samples.

Cancers (Basel). 2020-4-10

[6]
Optimization of rVAR2-Based Isolation of Cancer Cells in Blood for Building a Robust Assay for Clinical Detection of Circulating Tumor Cells.

Int J Mol Sci. 2020-3-31

[7]
Rapid Label-Free Isolation of Circulating Tumor Cells from Patients' Peripheral Blood Using Electrically Charged FeO Nanoparticles.

ACS Appl Mater Interfaces. 2020-1-14

[8]
Engineering magnetic nanoparticles and their integration with microfluidics for cell isolation.

J Colloid Interface Sci. 2019-12-23

[9]
Biomimetic Microfluidic System for Fast and Specific Detection of Circulating Tumor Cells.

Anal Chem. 2019-11-25

[10]
Superparamagnetic nanoarchitectures for disease-specific biomarker detection.

Chem Soc Rev. 2019-12-9

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