Translational Genomics Laboratory, Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.
Department of Biosciences, COMSATS University Islamabad (CUI), Islamabad, 45550, Pakistan.
Sci Rep. 2024 Sep 29;14(1):22580. doi: 10.1038/s41598-024-67221-4.
Circulating tumour cells (CTCs), derived from primary tumours, play a pivotal role in cancer metastasis by migrating into the peripheral bloodstream. These cells are paramount in clinical research, serving as early diagnostic markers for metastatic cancer. Analysing CTC counts and their biomarker characteristics can provide invaluable insights into tumour identification, profiling, and metastatic capabilities. However, the rarity and diverse nature of CTCs in the bloodstream present significant challenges to their isolation and detection, especially in the initial stages of metastasis. Recent advancements in nanotechnology have led to the development of innovative CTC separation and detection methods. This review focuses on applying nanoparticles, nanomaterials, and microfluidic platforms to simplify the isolation and detection of CTCs. The infusion of nanotechnology in this field marks a crucial turning point, enabling the necessary progress to advance CTC research.
循环肿瘤细胞（CTCs）来源于原发性肿瘤，通过迁移进入外周血液系统在癌症转移中发挥关键作用。这些细胞在临床研究中至关重要，是转移性癌症的早期诊断标志物。分析 CTC 的数量及其生物标志物特征可以为肿瘤识别、分析和转移能力提供宝贵的见解。然而，血液中 CTC 的稀有性和多样性对其分离和检测带来了巨大的挑战，特别是在转移的初始阶段。纳米技术的最新进展已经导致了创新的 CTC 分离和检测方法的发展。这篇综述重点介绍了应用纳米粒子、纳米材料和微流控平台来简化 CTC 的分离和检测。纳米技术在这一领域的应用标志着一个关键的转折点，使 CTC 研究取得必要的进展成为可能。
