Hu C F, Lin H, Chen Y J, Dai H T, Wang B Z, Xue L Y
Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Department of Medical Record, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhonghua Zhong Liu Za Zhi. 2020 Nov 23;42(11):943-948. doi: 10.3760/cma.j.cn112152-20200305-00171.
To investigate regional distribution and clinicopathological features of Epstein-Barr virus associated gastric cancer (EBVaGC). Epstein-Barr virus encoded RNA (EBER)was detected in 4 081 cases of gastric adenocarcinoma in Cancer Hospital, Chinese Academy of Medical Sciences by using in situ hybridization. EBVaGCs were identified and their proportions in different provinces, autonomous regions and municipalities were compared. The correlation between EBVaGC and clinicopathological features was also analyzed. A total of 3.0% (123/4 081) patients with gastric adenocarcinoma are EBVaGCs. Among the areas with cases more than 90, the highest proportion of EBVaGC was found in Jilin province, accounting for 7.6%, and then followed by 5.4% in Liaoning province, 4.1% in Anhui province, 3.9% in Beijing, 3.7% in Inner Mongolia Autonomous Region, 3.4% in Shanxi province, 3.0% in Heilongjiang province, 2.1% in Shandong province, 1.6% in Hebei province, and no EBVaGC was found in Henan province. EBVaGC proportions are significantly different in these provinces, autonomous regions and municipalities (<0.05). Multivariate analysis of logistic regression revealed that gender (=2.231, 95% 1.2903.858), WHO classification (=2.338, 95% 2.0512.664) and N stage (=0.420, 95% 0.284~0.621) were independent impact factors for EBVaGC. The proportion of EBVaGC was higher in males, gastric carcinomas accompanied with lymphoid stroma and patients without lymph node metastasis. The proportion of EBVaGC in gastric adenocarcinoma displays area distribution disparity in China. The gender, WHO classification and N stage are closely associated with EBVaGC.
探讨爱泼斯坦-巴尔病毒相关胃癌（EBVaGC）的区域分布及临床病理特征。采用原位杂交技术检测中国医学科学院肿瘤医院4081例胃腺癌中爱泼斯坦-巴尔病毒编码RNA（EBER）。识别EBVaGC并比较其在不同省、自治区和直辖市中的比例。同时分析EBVaGC与临床病理特征之间的相关性。共有3.0%（123/4081）的胃腺癌患者为EBVaGC。在病例数超过90例的地区中，EBVaGC比例最高的是吉林省，占7.6%，其次是辽宁省的5.4%、安徽省的4.1%、北京的3.9%、内蒙古自治区的3.7%、山西省的3.4%、黑龙江省的3.0%、山东省的2.1%、河北省的1.6%，河南省未发现EBVaGC。这些省、自治区和直辖市的EBVaGC比例存在显著差异（<0.05）。logistic回归多因素分析显示，性别（=2.231，95% 1.2903.858）、WHO分类（=2.338，95% 2.0512.664）和N分期（=0.420，95% 0.284~0.621）是EBVaGC的独立影响因素。EBVaGC在男性、伴有淋巴间质的胃癌以及无淋巴结转移的患者中比例较高。EBVaGC在中国胃腺癌中的比例呈现地区分布差异。性别、WHO分类和N分期与EBVaGC密切相关。
