Department of Surgery, University of Washington School of Medicine, Seattle, Wash; Center for Lung Biology, University of Washington, Seattle, Wash; West Coast Exosortium (WestCo Exosortium), Seattle, Wash.
Center for Lung Biology, University of Washington, Seattle, Wash; West Coast Exosortium (WestCo Exosortium), Seattle, Wash; Department of Bioengineering, University of Washington, Seattle, Wash.
J Thorac Cardiovasc Surg. 2021 Feb;161(2):e129-e134. doi: 10.1016/j.jtcvs.2020.04.183. Epub 2020 Jun 18.
Innate and adaptive immunity both contribute to allorecognition mechanisms that drive rejection after lung transplantation. Classic allorecognition pathways have been extensively described, but there continues to be several unanswered questions. Exosome research appears to be a novel and potentially significant area of allorecognition research and could be the missing link that answers some existing questions. This article reviews literature that is associated with allorecognition pathways and the role of exosomes in alloreactivity.
先天免疫和适应性免疫都有助于同种异体识别机制，从而导致肺移植后的排斥反应。经典的同种异体识别途径已经得到了广泛的描述，但仍有几个悬而未决的问题。外泌体研究似乎是同种异体识别研究的一个新的、有潜在意义的领域，可能是回答一些现有问题的缺失环节。本文综述了与同种异体识别途径和外泌体在同种异体反应中的作用相关的文献。
