Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Suffolk, CB8 0UH, UK.
J Small Anim Pract. 2021 Feb;62(2):123-130. doi: 10.1111/jsap.13262. Epub 2020 Dec 1.
To describe the use of corneal autografts for repair of deep corneal defects in dogs.
Retrospective analysis of clinical records of dogs that received autologous corneal grafts.
Fifteen dogs (16 eyes) of different breed, age and gender were included. Brachycephalic breeds were overrepresented (10/15 dogs). Defects were unilateral in 14 dogs and bilateral in one dog, extended to at least 80% of the stromal thickness in all eyes, with descemetoceles in four eyes and corneal perforations in five eyes. Most ulcers (13/16 eyes) were located centrally. Corneal autografts were harvested from healthy peripheral cornea of the ipsilateral eye. The thickness of the autograft was limited to a set depth of 0.3 mm. The autograft was sutured into a previously debrided ulcer bed with a continuous or simple interrupted suture pattern using absorbable or non-absorbable suture material. Additional interventions included a partial temporary tarsorrhaphy and bandage contact lenses. Postoperatively patients received topical antibiotics and systemic anti-inflammatory drugs, and 12/15 dogs also received systemic antibiotics. Mean follow-up time was 54 days (2 to 462). In all eyes the donor site healed uneventfully with mild, persistent corneal fibrosis. Postoperative complications included autograft keratomalacia, graft dehiscence and corneal pigmentation. No patient required additional surgery. Good structural and functional outcome was accomplished in 14 of 16 eyes.
Autologous corneal grafts provide tectonic support and result in good corneal transparency in selected cases of dogs with deep to perforated corneal ulcerations.
描述犬深层角膜缺损采用自体角膜移植修复的方法。
回顾性分析接受自体角膜移植的犬的临床记录。
15 只不同品种、年龄和性别的犬（16 只眼）被纳入研究。短头犬种（10/15 只犬）占比过高。14 只犬为单侧病变，1 只犬为双侧病变，所有患眼的基质厚度至少有 80%受累，4 只眼出现角膜后弹力层膨出，5 只眼出现角膜穿孔。大多数溃疡（13/16 只眼）位于中央。自体角膜取自同侧眼健康的周边角膜，厚度限制在 0.3mm。将自体移植物缝合至先前清创的溃疡床，使用可吸收或不可吸收缝线以连续或间断缝合方式缝合。其他干预措施包括部分暂时性睑裂缝合和绷带接触镜。术后患犬接受局部抗生素和全身抗炎药物治疗，12/15 只犬还接受全身抗生素治疗。平均随访时间为 54 天（2 至 462 天）。所有患眼供体部位均愈合良好，仅有轻微、持续的角膜纤维化。术后并发症包括自体移植物角膜软化、移植物裂开和角膜色素沉着。无患者需要再次手术。16 只眼中的 14 只眼获得了良好的结构和功能结果。
在选择的深层至穿孔性角膜溃疡犬中，自体角膜移植可提供结构支持，并获得良好的角膜透明度。
