OpenBiome, Cambridge, Massachusetts, USA.
Clin Transl Gastroenterol. 2020 Nov;11(11):e00247. doi: 10.14309/ctg.0000000000000247.
Although fecal microbiota transplantation (FMT) is a recommended, clinically efficacious, and cost-effective treatment for recurrent Clostridioides difficile infection (CDI), the scale of FMT use in the United States is unknown.
We developed a population-level CDI model.
We estimated that 48,000 FMTs could be performed annually, preventing 32,000 CDI recurrences.
Improving access to FMT could lead to tens of thousands fewer C. difficile episodes per year.
尽管粪便微生物群移植（FMT）是一种被推荐的、临床有效的、具有成本效益的复发性艰难梭菌感染（CDI）治疗方法，但 FMT 在全美范围内的使用规模尚不清楚。
我们开发了一个人群水平的 CDI 模型。
我们估计每年可以进行 48000 次 FMT，可以预防 32000 例 CDI 复发。
改善 FMT 的可及性每年可减少数万例艰难梭菌感染。
