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金属有机骨架的抗菌应用和毒性。

Antibacterial application and toxicity of metal-organic frameworks.

机构信息

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.

出版信息

Nanotoxicology. 2021 Apr;15(3):311-330. doi: 10.1080/17435390.2020.1851420. Epub 2020 Dec 1.

Abstract

Metal-organic frameworks (MOFs), which are also referred to as coordination polymers, have been widely used in adsorption separation and catalysis, especially in the field of physical chemistry in the past few years, because of their unique physical structure and potential chemical properties. In recent years, particularly with the continuous expansion of the research field, deepening of research levels, and sustained advancements in science and technology, powerful and diverse MOFs that have demonstrated great biomedical application potential have been successively developed. Consequently, this study summarizes the origin, development, and common synthesis methods of MOFs, with major emphasis on their antibacterial application and safety evaluation in biomedicine.

摘要

金属-有机骨架(MOFs),也称为配位聚合物,由于其独特的物理结构和潜在的化学性质,在过去几年中已在吸附分离和催化等领域得到了广泛应用,尤其是在物理化学领域。近年来,随着研究领域的不断扩大、研究水平的不断深化以及科学技术的持续进步,相继开发出了具有强大且多样的生物医学应用潜力的 MOFs。因此,本研究总结了 MOFs 的起源、发展和常见的合成方法,重点介绍了其在生物医学中的抗菌应用和安全性评价。

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