Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America.
Center for Food Safety and Applied Nutrition, Office of Analytics and Outreach, U.S. Food and Drug Administration, College Park, Maryland, United States of America.
PLoS One. 2020 Dec 1;15(12):e0239099. doi: 10.1371/journal.pone.0239099. eCollection 2020.
The association of body mass index (BMI) and waist circumference (WC) with risk of Guillain-Barré syndrome (GBS) has been inconsistent in previous studies.
We examined the associations of BMI and WC in relation to risk of GBS among 252,980 participants from the Nurses' Health Study (NHS), NHS-II, and the Health Professional Follow-up Study (HPFS). BMI and WC were assessed by self-reported questionnaire, and GBS cases were self-reported.
We documented 328 incident GBS cases during a total of 5,422,788 person years of follow-up. Compared to participants with BMI<25kg/m2, the multivariate pooled hazard ratio (HR) of GBS was 1.34 (95% CI: 1.04, 1.73) for overweight participants (25kg/m2≤BMI<30 kg/m2), and 1.68 (95% CI: 1.21, 2.35) for obese participants (BMI≥30 kg/m2) (P for trend = 0.001). Compared to participants with normal WC (<35 inches for women and <40 inches for men), the HR of GBS was 1.55 (95% CI: 1.10, 2.18) for participants with high WC (≥35 inches for women, and ≥40 inches for men). The positive associations of BMI and WC with risk of GBS were attenuated to null after mutually adjusting for BMI and WC. Joint analysis showed that the HR was 1.84 (95% CI: 1.27, 2.66) for participants with high WC and BMI≥25 kg/m2 in comparison to participants with normal WC and BMI<25kg/m2.
These data from large cohorts showed that higher BMI and WC jointly were associated with higher risk of GBS. Our study highlighted the importance of maintaining a normal body weight and waist circumference in prevention of GBS.
体重指数（BMI）和腰围（WC）与格林-巴利综合征（GBS）风险的关联在之前的研究中并不一致。
我们研究了护士健康研究（NHS）、NHS-II 和健康专业人员随访研究（HPFS）中 252980 名参与者的 BMI 和 WC 与 GBS 风险之间的关系。BMI 和 WC 通过自我报告问卷评估，GBS 病例通过自我报告。
在总共 5422788 人年的随访中，我们记录了 328 例 GBS 新发病例。与 BMI<25kg/m2 的参与者相比，超重（25kg/m2≤BMI<30kg/m2）参与者的 GBS 多变量合并危险比（HR）为 1.34（95%CI：1.04，1.73），肥胖（BMI≥30kg/m2）参与者为 1.68（95%CI：1.21，2.35）（趋势 P 值=0.001）。与正常 WC（女性<35 英寸，男性<40 英寸）的参与者相比，WC 较高（女性≥35 英寸，男性≥40 英寸）的参与者的 GBS HR 为 1.55（95%CI：1.10，2.18）。在相互调整 BMI 和 WC 后，BMI 和 WC 与 GBS 风险的正相关减弱至无统计学意义。联合分析显示，与正常 WC 和 BMI<25kg/m2 的参与者相比，WC 较高且 BMI≥25kg/m2 的参与者的 HR 为 1.84（95%CI：1.27，2.66）。
这些来自大型队列的研究数据表明，较高的 BMI 和 WC 与 GBS 风险升高相关。我们的研究强调了保持正常体重和腰围对预防 GBS 的重要性。
