Department of Internal Medicine, College of Medicine, Hanyang University, Seoul 04763, Korea.
Department of Internal Medicine, College of Medicine, Korea University, Seoul 02841, Korea.
Medicina (Kaunas). 2020 Nov 29;56(12):659. doi: 10.3390/medicina56120659.
: We aimed to analyze factors associated with the period of viral shedding in patients with confirmed COVID-19 who experienced only mild symptoms. : We conducted a multicenter retrospective study from three community treatment centers (CTCs) of South Korea. All patients included were admitted to the three centers before 31 March 2020. We collected data about clinical characteristics and the result of real-time reverse transcription polymerase chain reaction (RT-PCR). : Viral shedding was terminated within 32 days and 36 days in 75% and 90% of patients, respectively (range: 8-49 days). The mean period of viral shedding was 23.8 ± 8.7 days. In the multivariate Cox proportional hazards regression analysis, the existence of underlying comorbidities lowered the probability of the termination of viral shedding (HR = 0.561, 95% CI 0.388-0.812). Female sex and presence of COVID-19-associated symptoms also lowered the probability, but the significance was marginal. : The existence of underlying comorbidities was associated with delayed termination of viral shedding in COVID-19 patients with mild severity.
我们旨在分析仅出现轻度症状的确诊 COVID-19 患者病毒脱落期的相关因素。
我们进行了一项多中心回顾性研究，纳入了韩国的 3 家社区治疗中心（CTCs）的患者。所有纳入的患者均在 2020 年 3 月 31 日前入住这 3 家中心。我们收集了临床特征和实时逆转录聚合酶链反应（RT-PCR）结果的数据。
分别有 75%和 90%的患者（范围：8-49 天）的病毒脱落期在 32 天和 36 天内终止，病毒脱落的平均持续时间为 23.8±8.7 天。在多变量 Cox 比例风险回归分析中，基础合并症的存在降低了病毒脱落终止的概率（HR=0.561，95%CI 0.388-0.812）。女性和 COVID-19 相关症状的存在也降低了这种概率，但意义不大。
基础合并症的存在与 COVID-19 轻症患者病毒脱落期的延长有关。
