Cawthon Claire V, Cooper Kathryn, Huett Clifton, Lloret Alyssa, Villar-Matamoros Estefanny, Stokes Lauren, Christians Uwe, Schuler Michele, Yazdani Saami K
Department of Mechanical Engineering, University of South Alabama, Mobile, AL 36688, USA.
Department of Engineering, Wake Forest University, Winston-Salem, NC 27101, USA.
Pharmaceuticals (Basel). 2020 Nov 28;13(12):434. doi: 10.3390/ph13120434.
The purpose of this pilot study was to investigate the feasibility of a perfusion catheter to deliver liquid paclitaxel into arterial segments. A clinically relevant rabbit ilio-femoral injury model was utilized to determine the impact of liquid paclitaxel delivered locally into the vessel wall using a perfusion catheter at 1 h to 14 days. Treatment by two clinically available forms of liquid paclitaxel, a solvent-based (sb) versus an albumin-bound (nab), along with a control (uncoated balloons), were investigated. Pharmacokinetic results demonstrated an increase in the retention of the sb-paclitaxel versus the nab-paclitaxel at 1 h; however, no other differences were observed at days one, three, and seven. Histological findings at 14 days showed significantly less neointimal area in the sb-paclitaxel treated arteries as compared with the nab-paclitaxel and the uncoated balloon-treated arteries. Additionally, percent area stenosis was significantly less in the sb-paclitaxel group. These results support the concept of local liquid delivery of paclitaxel into the arterial segments.
这项初步研究的目的是探讨灌注导管将液态紫杉醇输送至动脉节段的可行性。利用一种临床相关的兔髂股损伤模型，来确定在1小时至14天期间，使用灌注导管将液态紫杉醇局部输送至血管壁的影响。研究了两种临床可用的液态紫杉醇形式，即溶剂型（sb）与白蛋白结合型（nab），以及对照（未涂层球囊）的治疗效果。药代动力学结果表明，在1小时时，sb-紫杉醇的滞留量相对于nab-紫杉醇有所增加；然而，在第1天、第3天和第7天未观察到其他差异。14天时的组织学结果显示，与nab-紫杉醇和未涂层球囊治疗的动脉相比，sb-紫杉醇治疗的动脉新生内膜面积显著更小。此外，sb-紫杉醇组的面积狭窄百分比显著更低。这些结果支持了将紫杉醇局部液体输送至动脉节段的概念。
