奥科梯隆型皂苷的发现、半合成、生物活性及代谢
Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.
作者信息
Liu Juan, Xu Yangrong, Yang Jingjing, Wang Wenzhi, Zhang Jianqiang, Zhang Renmei, Meng Qingguo
机构信息
School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China.
出版信息
J Ginseng Res. 2017 Jul;41(3):373-378. doi: 10.1016/j.jgr.2017.01.001. Epub 2017 Jan 13.
Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in L., , , and Vietnamese ginseng. In recent years, the semisynthesis of 20(/)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, antimyocardial ischemia, antiinflammatory, antibacterial, and antitumor activities. Owing to their chemical structure, pharmacological actions, and the stereoselective activity on antimyocardial ischemia, ocotillol-type saponins are subjected to extensive consideration. In this review, we sum up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.
奥科梯隆型皂苷是一类四环三萜类化合物，具有一个四氢呋喃环。在人参、三七、竹节参和越南人参中发现了天然的奥科梯隆型皂苷。近年来，已有关于20（/）-奥科梯隆型皂苷半合成的报道。奥科梯隆型皂苷的生物活性包括神经保护作用、抗心肌缺血、抗炎、抗菌和抗肿瘤活性。由于其化学结构、药理作用以及对抗心肌缺血的立体选择性活性，奥科梯隆型皂苷受到了广泛关注。在这篇综述中，我们总结了奥科梯隆型皂苷的发现、半合成、生物活性和代谢情况。
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