Department of Public Health, University of Naples Federico II, 80131 Naples, Italy.
Cells. 2020 Nov 27;9(12):2549. doi: 10.3390/cells9122549.
Gain-of-function of V-Raf Murine Sarcoma Viral Oncogene Homolog B () is one of the most frequent oncogenic mutations in numerous cancers, including thyroid papillary carcinoma, melanoma, colon, and lung carcinomas, and to a lesser extent, ovarian and glioblastoma multiforme. This mutation aberrantly activates the mitogen-activated protein (MAP) kinase extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway, thereby eliciting metastatic processes. The relevance of mutations stems from its prognostic value and, equally important, from its relevant therapeutic utility as an actionable target for personalized treatment. Here, we discuss the double facets of . In particular, we argue the need to implement diagnostic molecular algorithms that are able to detect this biomarker in order to streamline and refine diagnostic and therapeutic decisions.
V-Raf 鼠肉瘤病毒癌基因同源物 B() 的功能获得性突变是多种癌症中最常见的致癌突变之一，包括甲状腺乳头状癌、黑色素瘤、结肠癌和肺癌，在卵巢癌和多形性胶质母细胞瘤中则较少见。这种突变异常激活丝裂原活化蛋白（MAP）激酶细胞外信号调节激酶（MEK）/细胞外信号调节激酶（ERK）信号通路，从而引发转移过程。突变的相关性源于其预后价值，同样重要的是，它作为个性化治疗的可操作靶点具有相关的治疗用途。在这里，我们讨论了的双重性。特别是，我们认为需要实施诊断分子算法，以检测该生物标志物，从而简化和优化诊断和治疗决策。
