Centre for Analysis and Synthesis (CAS), Department of Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.
OQ, SablaX, P.O Box 261, P.C 118 Muscat, Oman.
Molecules. 2020 Nov 27;25(23):5582. doi: 10.3390/molecules25235582.
The solubility of quercetin and its thermal degradation was studied in CO-expanded ethanol and ethyl lactate. An equipment setup was constructed that enabled the separation of the products of degradation while quantifying the solubility of quercetin. Three different conditions of temperature were analyzed (308, 323, and 343 K) at 10 MPa. Higher solubility and thermal degradation of quercetin were observed for CO-expanded ethyl lactate in comparison with CO-expanded ethanol. At the same time, as the amount of CO was increased in the CO-expanded liquids mixtures, the thermal degradation of quercetin decreased for almost all the conditions of temperature considered in this work. The importance of considering thermal degradation while performing solubility measurements of compounds that are thermally unstable such as quercetin was highlighted.
在 CO 增溶乙醇和乳酸乙酯中研究了槲皮素的溶解度及其热降解。构建了一种设备装置，可在定量测定槲皮素溶解度的同时分离降解产物。分析了 3 种不同温度条件（308、323 和 343 K）下的 10 MPa。与 CO 增溶乙醇相比，CO 增溶乳酸乙酯时观察到槲皮素具有更高的溶解度和热降解。同时，随着 CO 在 CO 增溶混合液中含量的增加，在本工作考虑的几乎所有温度条件下，槲皮素的热降解都降低。强调了在对热不稳定化合物（如槲皮素）进行溶解度测量时考虑热降解的重要性。
