Shadmehr Reza, Ahmed Alaa A
Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, 21205,
Department of Mechanical Engineering and Department of Integrative Physiology, University of Colorado, Boulder, CO80027, USA.
Behav Brain Sci. 2020 Dec 2;44:e123. doi: 10.1017/S0140525X20000667.
Why do we run toward people we love, but only walk toward others? Why do people in New York seem to walk faster than other cities? Why do our eyes linger longer on things we value more? There is a link between how the brain assigns value to things, and how it controls our movements. This link is an ancient one, developed through shared neural circuits that on one hand teach us how to value things, and on the other hand control the vigor with which we move. As a result, when there is damage to systems that signal reward, like dopamine and serotonin, that damage not only affects our mood and patterns of decision-making, but how we move. In this book, we first ask why, in principle, evolution should have developed a shared system of control between valuation and vigor. We then focus on the neural basis of vigor, synthesizing results from experiments that have measured activity in various brain structures and neuromodulators, during tasks in which animals decide how patiently they should wait for reward, and how vigorously they should move to acquire it. Thus, the way we move unmasks one of our well-guarded secrets: how much we value the thing we are moving toward.
为什么我们会跑向我们爱的人,却只是走向其他人?为什么纽约人似乎比其他城市的人走得更快?为什么我们的眼睛会在我们更看重的事物上停留更长时间?大脑对事物赋予价值的方式与它控制我们行动的方式之间存在联系。这种联系由来已久,是通过共享的神经回路发展而来的,这些神经回路一方面教会我们如何评估事物的价值,另一方面控制我们行动的力度。因此,当向大脑传递奖励信号的系统(如多巴胺和血清素)受损时,这种损伤不仅会影响我们的情绪和决策模式,还会影响我们的行动方式。在这本书中,我们首先探讨为什么从原则上讲,进化会发展出一种在评估价值和行动力度之间的共享控制系统。然后,我们将重点关注行动力度的神经基础,综合在动物决定应该多耐心等待奖励以及应该多积极行动以获取奖励的任务中,测量各种脑结构和神经调质活动的实验结果。因此,我们的行动方式揭示了一个我们严加守护的秘密:我们对正在走向的事物有多看重。
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