Liu Hongyun, Hei Shumin, Wang Jigang, Zhang Qiliang, Yu Xinjuan, Chen Hua
Department of Pathology, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China.
Department of Pathology, School of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, P.R. China.
Mol Clin Oncol. 2021 Jan;14(1):7. doi: 10.3892/mco.2020.2169. Epub 2020 Nov 12.
Dendritic fibromyxolipoma (DFML) is a rare variant of spindle cell lipoma. It is characterized by extensive myxoid change and the presence of stellate cells with dendritic processes. The present study reports three cases of DFML that arose from the limbs and thoracic cavity. Pathologically, the tumor was composed of mature adipocytes admixing with patch spindle cells in a myxoid stroma. The cell atypia was not apparent and mitotic figures were rare. Immunohistochemistry revealed that the spindle cells were strongly positive for CD34. The three patients demonstrated no significant issues during a two-year's follow-up without evidence of recurrence and metastasis. The current study additionally reviewed all reported DFML cases in the PubMed database and Chinese journals.
树突状纤维黏液脂肪瘤（DFML）是梭形细胞脂肪瘤的一种罕见变体。其特征为广泛的黏液样改变以及存在具有树突状突起的星状细胞。本研究报告了3例发生于四肢和胸腔的DFML病例。病理上，肿瘤由成熟脂肪细胞与黏液样基质中的散在梭形细胞混合组成。细胞异型性不明显，有丝分裂象罕见。免疫组化显示梭形细胞CD34呈强阳性。3例患者在两年随访期间无明显问题，无复发和转移迹象。本研究还回顾了PubMed数据库和中文期刊中所有已报道的DFML病例。
